Inhibition of the Human Immunodeficiency Virus Type 1 DNA Integration by Modified Oligonucleotides

被引：0
|
作者：
M. D. Pinskaya
P. Brodin
E. A. Romanova
E. M. Volkov
J.-F. Mouscadet
M. B. Gottikh
机构：
[1] Moscow State University,Chemical Faculty
[2] CNRS-UMR 8532,Belozersky Institute of Physico
[3] Institut Gustave Roussy,Chemical Biology
[4] Moscow State University,undefined
来源：
Molecular Biology | 2000年 / 34卷
关键词：
HIV-1; integration; oligonucleotide; quadruplex; triplex-forming oligonucleotide; parallel duplex; phosphorothioate oligonucleotide;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Oligonucleotide inhibitors of the HIV-1 DNA integration identified to date are reviewed. Two basic strategies of blocking the integration are considered: shielding the integrase-binding sites on the viral DNA by triplex-forming oligonucleotides, and directly inhibiting the enzyme with oligonucleotide agents.
引用
收藏
页码：888 / 894
页数：6
相关论文
共 50 条
  • [11] Alpha-enolase in viral target cells suppresses the human immunodeficiency virus type 1 integration
    Kishimoto, Naoki
    Yamamoto, Kengo
    Iga, Nozomi
    Kirihara, Chie
    Abe, Towa
    Takamune, Nobutoki
    Misumi, Shogo
    RETROVIROLOGY, 2020, 17 (01)
  • [12] Repression of the human immunodeficiency virus type 1 promoter by the human KRAB domain results in inhibition of virus production
    Herchenröder, O
    Hahne, JC
    Meyer, WKH
    Thiesen, HJ
    Schneider, J
    BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION, 1999, 1445 (02): : 216 - 223
  • [13] A three-dimensional model of the human immunodeficiency virus type 1 integration complex
    Wielens, J
    Crosby, IT
    Chalmers, DK
    JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN, 2005, 19 (05) : 301 - 317
  • [14] Assembling the human immunodeficiency virus type 1
    Cimarelli, A
    Darlix, JL
    CELLULAR AND MOLECULAR LIFE SCIENCES, 2002, 59 (07) : 1166 - 1184
  • [15] Inhibition of Human Immunodeficiency Virus Type 1 by Triciribine Involves the Accessory Protein Nef
    Ptak, Roger G.
    Gentry, Brian G.
    Hartman, Tracy L.
    Watson, Karen M.
    Osterling, M. Clayton
    Buckheit, Robert W., Jr.
    Townsend, Leroy B.
    Drach, John C.
    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2010, 54 (04) : 1512 - 1519
  • [16] Inhibition of human immunodeficiency virus type 1 replication by transdominant mutant Tat proteins
    白龙川
    袁建刚
    胡松年
    赵全璧
    邵一鸣
    强伯勤
    Progress in Natural Science, 1998, (06) : 56 - 60
  • [17] Human Immunodeficiency Virus Type 1 Modified To Package Simian Immunodeficiency Virus Vpx Efficiently Infects Macrophages and Dendritic Cells
    Sunseri, Nicole
    O'Brien, Meagan
    Bhardwaj, Nina
    Landau, Nathaniel R.
    JOURNAL OF VIROLOGY, 2011, 85 (13) : 6263 - 6274
  • [18] Small-Molecule Inhibition of Human Immunodeficiency Virus Type 1 Infection by Virus Capsid Destabilization
    Shi, Jiong
    Zhou, Jing
    Shah, Vaibhav B.
    Aiken, Christopher
    Whitby, Kevin
    JOURNAL OF VIROLOGY, 2011, 85 (01) : 542 - 549
  • [19] The central DNA flap of the human immunodeficiency virus type 1 is important for viral replication
    De Rijck, Jan
    Debyser, Zeger
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2006, 349 (03) : 1100 - 1110
  • [20] Integration of human immunodeficiency virus type 1 in untreated infection occurs preferentially within genes
    Liu, Hongbing
    Dow, Eugene C.
    Arora, Reetakshi
    Kimata, Jason T.
    Bu, Lara M.
    Arduino, Roberto C.
    Rice, Andrew P.
    JOURNAL OF VIROLOGY, 2006, 80 (15) : 7765 - 7768
12345