Triamterene in lithium-induced nephrogenic diabetes insipidus: a case report

被引：0
作者：
Megumi Inoue
Kentaro Nakai
Koji Mitsuiki
机构：
[1] Japanese Red Cross Fukuoka Hospital,Division of Nephrology and Dialysis Center
来源：
CEN Case Reports | 2021年 / 10卷
关键词：
Hypercalcemia; Hypernatremia; Hyperparathyroidism; Lithium intoxication; Polyuria;
D O I：
暂无
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学科分类号：
摘要：
Lithium-induced nephrogenic diabetes insipidus (NDI) is a rare and difficult-to-treat condition. We describe the case of an 81-year-old woman with bipolar treated with lithium and no previous history of diabetes insipidus. She was hospitalized due to disturbance of consciousness and was diagnosed with, hypercalcemia, hyperparathyroidism, and NDI. Parathyroidectomy was contraindicated and parathyroid hormone level was improved insufficiently after cinacalcet initiation, percutaneous ethanol injection therapy was performed for the enlarged parathyroid gland. After improvement in hypercalcemia and unsuccessful indapamide treatment, triamterene was administrated to control polyuria. Lithium is one of the indispensable maintenance treatment options for bipolar disorder, but it has the side effect of NDI. Lithium enters the collecting duct’s principal cells mainly via the epithelial sodium channel (ENaC) located on their apical membranes, ENaC shows high selectivity for both sodium and lithium, is upregulated by aldosterone, and inhibited by triamterene. To our knowledge, this is the first publication on triamterene use in lithium-induced NDI patients.
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页码：64 / 68
页数：4
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