Jejunal Infusion of Levodopa–Carbidopa Intestinal Gel Versus Oral Administration of Levodopa–Carbidopa Tablets in Japanese Subjects with Advanced Parkinson’s Disease: Pharmacokinetics and Pilot Efficacy and Safety

被引：0
作者：
Ahmed A. Othman
Krai Chatamra
Mohamed-Eslam F. Mohamed
Sandeep Dutta
Janet Benesh
Masayoshi Yanagawa
Masahiro Nagai
机构：
[1] AbbVie,Clinical Pharmacology and Pharmacometrics
[2] Cairo University,Department of Pharmaceutics, Faculty of Pharmacy
[3] AbbVie,Neuroscience Development
[4] AbbVie GK,Clinical Therapeutic Trial Center
[5] Ehime University Hospital,undefined
来源：
Clinical Pharmacokinetics | 2015年 / 54卷
关键词：
Levodopa; Japanese Subject; Caucasian Subject; Carbidopa; Duodopa;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
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收藏
页码：975 / 984
页数：9
相关论文
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[1]  
Hauser RA(2009)Levodopa: past, present, and future Eur Neurol 62 1-8
[2]  
Ahlskog JE(2001)Frequency of levodopa-related dyskinesias and motor fluctuations as estimated from the cumulative literature Mov Disord 16 448-458
[3]  
Muenter MD(2013)Pharmacokinetics of levodopa, carbidopa, and 3- AAPS J. 15 316-323
[4]  
Nyholm D(2007)-methyldopa following 16-h jejunal infusion of levodopa-carbidopa intestinal gel in advanced Parkinson’s disease patients Parkinsonism Relat Disord. 13 S13-S17
[5]  
Odin P(1984)The rationale for continuous dopaminergic stimulation in advanced Parkinson’s disease Clin Neuropharmacol 7 35-49
[6]  
Johansson A(2001)Pharmacokinetics of levodopa Mov Disord 16 1041-1047
[7]  
Chatamra K(1988)Gastric emptying time and gastric motility in patients with Parkinson’s disease Neurology. 38 419-421
[8]  
Locke C(1984)Erratic gastric emptying of levodopa may cause “random” fluctuations of parkinsonian mobility N Engl J Med 310 483-488
[9]  
Dutta S(1994)The “on-off” phenomenon in Parkinson’s disease. Relation to levodopa absorption and transport Neurology. 44 913-919
[10]  
Nyholm D(2004)Effect of peripheral catechol- Clin Neuropharmacol. 27 245-256
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