Contact lens-related polymicrobial keratitis: Acanthamoeba spp. genotype T4 and Candida albicans

被引：0
作者：
Maria Luiza Carneiro Buchele
Débora Borgert Wopereis
Fabiana Casara
Jefferson Peres de Macedo
Marilise Brittes Rott
Fabíola Branco Filippin Monteiro
Maria Luiza Bazzo
Fernando dos Reis Spada
Jairo Ivo dos Santos
Karin Silva Caumo
机构：
[1] Universidade Federal de Santa Catarina (UFSC),Centro de Ciências da Saúde, Departamento de Análises Clínicas, Laboratório de Estudos de Protozoários Emergentes e Oportunistas
[2] Universidade Federal do Rio Grande do Sul (UFRGS),Instituto de Ciências Básicas da Saúde, Departamento de Microbiologia, Imunologia e Parasitologia
[3] Universidade Federal de Santa Catarina (UFSC),Centro de Ciências da Saúde, Departamento de Análises Clínicas, Laboratório de Biologia Molecular, Sorologia e Micobactérias
[4] Hospital Regional de São José - Homero de Miranda Gomes,Centro de Ciências da Saúde, Departamento de Análises Clínicas, Laboratório de Micologia Clínica
[5] Setor de oftalmologia,undefined
[6] Universidade Federal de Santa Catarina (UFSC),undefined
来源：
Parasitology Research | 2018年 / 117卷
关键词：
Infectious keratitis; spp.; Contact lenses;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
A 31-year-old female daily user of contact lenses sought medical attention, reporting blurred vision and irritation of the left eye. Slit-lamp examination revealed hyperemia and an irregular corneal epithelium surface, and empirical treatment was started. A corneal scrape was obtained and examined for the presence of fungi, bacteria, and Acanthamoeba spp. The results of the microbial culture revealed growth of Acanthamoeba spp. and Candida albicans. The Acanthamoeba isolate was characterized by cyst morphology as belonging to group II according to Pussard and Pons. Sequencing of the diagnostic fragment 3 (DF3) region located on the 18S ribosomal DNA identified the isolate as genotype T4. The patient was treated with chlorhexidine 0.02% and polyhexamethylene biguanide (PHMB) 0.02% drops for 5 months until the infection resolved. Lately, rare cases of polymicrobial keratitis associated with Acanthamoeba and Candida albicans have been reported. Cases of co-infection are more difficult to treat, since the specific treatment depends on precise identification of the agents involved.
引用
收藏
页码：3431 / 3436
页数：5
相关论文
共 174 条
  • [1] Aitken D(1996)Amebic keratitis in a wearer of disposable contact lenses due to a mixed Vahlkampfia and Hartmannella infection Ophthalmology 103 485-494
  • [2] Hay J(2017)Contact lens-related complications: a review J Ophthalmic Vis Res 12 193-204
  • [3] Kinnear FB(2017)Free-Living Amoebae as Hosts for and Vectors of Intracellular Microorganisms with Public Health Significance Viruses 9 65-1693
  • [4] Kirkness CM(2005)Identification and distribution of Acanthamoeba species genotypes associated with nonkeratitis infections J Clin Microbiol 43 1689-204
  • [5] Lee WR(2011)Microbial keratitis at a referral center in Brazil Int Ophthalmol 31 197-92
  • [6] Seal DV(2016)Strategies for the prevention of contact lens-related Acanthamoeba keratitis: a review Ophthalmic Physiol Opt 36 77-218
  • [7] Alipour F(2017)Therapeutic agents and biocides for ocular infections by free-living amoebae of Acanthamoeba genus Surv Ophthalmol 62 203-870
  • [8] Khaheshi S(2015)Contact lens wearer demographics and risk behaviors for contact lens-related eye infections--United States, 2014 MMWR Morb Mortal Wkly Rep 64 865-2490
  • [9] Soleimanzadeh M(2015)Acanthamoeba misidentification and multiple labels: redefining genotypes T16, T19, and T20 and proposal for Acanthamoeba Micheli sp. nov. (genotype T19) Parasitol Res 14 2481-1284
  • [10] Heidarzadeh S(2017)Update on Acanthamoeba Jacobsi genotype T15, including full-length 18s RDNA molecular phylogeny Parasitol Res 116 1273-108
12345678910