The partner-swapping sliding clamp loader exposed

被引：0
|
作者：
David Jeruzalmi
机构：
[1] City College of New York,Department of Chemistry and Biochemistry
[2] The Graduate Center of the City University of New York,PhD Program in Biochemistry
[3] The Graduate Center of the City University of New York,PhD Program in Biology
[4] The Graduate Center of the City University of New York,PhD Program in Chemistry
来源：
Nature Structural & Molecular Biology | 2022年 / 29卷
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摘要：
Eukaryotes possess several clamp loaders comprising four common subunits and a fifth subunit unique to each complex. The RFC-A–E clamp loader loads the PCNA clamp at 3′-recessed structures for DNA replication. However, swapping a single subunit, Rad24, for RFC-A yields a clamp loader that prefers the 911 clamp and 5′-recessed DNA. Three new studies reveal detailed views of the clamp loading reaction and provide insights into substrate preferences of each loader.
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页码：283 / 286
页数：3
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