Stem cell-based drug delivery strategy for skin regeneration and wound healing: potential clinical applications

被引:0
作者
Weiyue Zhang
Xin Huang
机构
[1] Union Hospital,Department of Endocrinology
[2] Tongji Medical College,Department of Orthopaedics
[3] Huazhong University of Science and Technology,undefined
[4] Union Hospital,undefined
[5] Tongji Medical College,undefined
[6] Huazhong University of Science and Technology,undefined
来源
Inflammation and Regeneration | / 43卷
关键词
Stem cell; Drug delivery strategy; Cell membrane-coating nanotechnology; Skin regeneration; Wound healing;
D O I
暂无
中图分类号
学科分类号
摘要
Stem cell-based therapy is widely accepted to be a promising strategy in tissue regenerative medicine. Nevertheless, there are several obstacles to applying stem cells in skin regeneration and wound healing, which includes determining the optimum source, the processing and administration methods of stem cells, and the survival and functions of stem cells in wound sites. Owing to the limitations of applying stem cells directly, this review aims to discuss several stem cell-based drug delivery strategies in skin regeneration and wound healing and their potential clinical applications. We introduced diverse types of stem cells and their roles in wound repair. Moreover, the stem cell-based drug delivery systems including stem cell membrane-coated nanoparticles, stem cell-derived extracellular vesicles, stem cell as drug carriers, scaffold-free stem cell sheets, and stem cell-laden scaffolds were further investigated in the field of skin regeneration and wound healing. More importantly, stem cell membrane-coating nanotechnology confers great advantages compared to other drug delivery systems in a broad field of biomedical contexts. Taken together, the stem cell-based drug delivery strategy holds great promise for treating skin regeneration and wound healing.
引用
收藏
相关论文
共 50 条
  • [31] Mesenchymal Stem Cell Extract Promotes Skin Wound Healing
    Deng, Zi
    Iwasaki, Kengo
    Peng, Yihao
    Honda, Yoshitomo
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2024, 25 (24)
  • [32] Programmed cell death in stem cell-based therapy: Mechanisms and clinical applications
    Hu, Xi-Min
    Zhang, Qi
    Zhou, Rui-Xin
    Wu, Yan-Lin
    Li, Zhi-Xin
    Zhang, Dan-Yi
    Yang, Yi-Chao
    Yang, Rong-Hua
    Hu, Yong-Jun
    Xiong, Kun
    WORLD JOURNAL OF STEM CELLS, 2021, 13 (05): : 386 - 415
  • [33] Skin tissue engineering: wound healing based on stem-cell-based therapeutic strategies
    Dehkordi, Azar Nourian
    Babaheydari, Fatemeh Mirahmadi
    Chehelgerdi, Mohammad
    Dehkordi, Shiva Raeisi
    STEM CELL RESEARCH & THERAPY, 2019, 10
  • [34] Skin tissue engineering: wound healing based on stem-cell-based therapeutic strategies
    Azar Nourian Dehkordi
    Fatemeh Mirahmadi Babaheydari
    Mohammad Chehelgerdi
    Shiva Raeisi Dehkordi
    Stem Cell Research & Therapy, 10
  • [35] Two-Stage Patterned Cell-Based Treatments for Skin Regeneration
    Chen, Chih-Long
    Tsai, Chieh-Yi
    Chen, Yu-Shan
    Lin, Teng-Yen
    Hsu, Yi-Jung
    Wei, Shih-Yen
    Chen, Ying-Chieh
    JOURNAL OF BIOMEDICAL NANOTECHNOLOGY, 2020, 16 (12) : 1740 - 1754
  • [36] Biomedical applications of Bombyx mori silk in skin regeneration and cutaneous wound healing
    Khosropanah, Mohammad Hossein
    Ghofrani, Alireza
    Vaghasloo, Mahdi Alizadeh
    Zahir, Mazyar
    Bahrami, Afshin
    Azimzadeh, Ashkan
    Hassannejad, Zahra
    Majidi Zolbin, Masoumeh
    BIOMEDICAL MATERIALS, 2025, 20 (02)
  • [37] Applications of drug delivery systems, organic, and inorganic nanomaterials in wound healing
    Lo, Samantha
    Mahmoudi, Ebrahim
    Fauzi, Mh Busra
    DISCOVER NANO, 2023, 18 (01)
  • [38] Calendula in modern medicine: Advancements in wound healing and drug delivery applications
    Ejiohuo, Ovinuchi
    Folami, Samson
    Maigoro, Abdulkadir Yusif
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY REPORTS, 2024, 12
  • [39] Applications of drug delivery systems, organic, and inorganic nanomaterials in wound healing
    Samantha Lo
    Ebrahim Mahmoudi
    Mh Busra Fauzi
    Discover Nano, 18
  • [40] The Role of Stem Cell on Wound Healing After Revascularization-Healing Following Revascularization-Unlocking Skin Potential
    Cheng, Biao
    Fu, Xiaobing
    INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS, 2024, 23 (01) : 63 - 69