Ameliorating activity of ginger (Zingiber officinale) extract against lead induced renal toxicity in male rats

被引：0
作者：
Y. Amarnath Reddy
M. Chalamaiah
B. Ramesh
G. Balaji
P. Indira
机构：
[1] Sri Krishnadevaraya University,Department of Zoology
[2] National Institute of Nutrition,Food and Drug Toxicology Research Centre
[3] Sri Venkateswara University,Department of Biochemistry
[4] Sri Krishnadevaraya University,Department of Pharmacology
来源：
Journal of Food Science and Technology | 2014年 / 51卷
关键词：
Lead toxicity; Ginger (; ) extract; Rat kidney; Glutathione (GSH); Glutathione dependent antioxidant enzymes;
D O I：
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中图分类号：
学科分类号：
摘要：
Lead poisoning has been known to be associated with structural and functional abnormalities of multiple organ systems of human body. The aim of this investigation was to study the renal protective effects of ginger (Zingiber officinale) extract in lead induced toxicity rats. In this study renal glutathione (GSH) level, glutathione peroxidase (GPX), glutathione-s-transferase (GST), and catalase enzymes were measured in lead nitrate (300 mg/kg BW), and lead nitrate plus ginger extract (150 mg/kg BW) treated rat groups for 1 week and 3 weeks respectively. The glutathione level and GSH dependent antioxidant enzymes such as glutathione peroxidase, glutathione-s-transferase, and catalase significantly (P < 0.05) increased in ginger extract treated rat groups. In addition, histological studies showed lesser renal changes in lead plus ginger extract treated rat groups than that of lead alone treated rat groups. These results indicate that ginger extract alleviated lead toxic effects by enhancing the levels of glutathione, glutathione peroxidase, glutathione-s-transferase and catalase.
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页码：908 / 914
页数：6
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