The endogenous inhibitor of Akt, CTMP, is critical to ischemia-induced neuronal death

被引：0

作者：

Takahiro Miyawaki

Dimitry Ofengeim

Kyung-Min Noh

Adrianna Latuszek-Barrantes

Brian A Hemmings

Antonia Follenzi

R Suzanne Zukin

机构：

[1] Rose F. Kennedy Center,Dominick P. Purpura Department of Neuroscience

[2] Albert Einstein College of Medicine,Department of Neurosurgery

[3] Jichi Medical University,Department of Pathology

[4] Friedrich Miescher Institute for Biomedical Research,undefined

[5] Marion Bessin Liver Research Center,undefined

[6] Albert Einstein College of Medicine,undefined

[7] University of Piemonte Orientale,undefined

[8] School of Medicine,undefined

来源：

Nature Neuroscience | 2009年 / 12卷

关键词：

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Akt signaling has been implicated in a number of diseases, but its role in brain disorders is less clear. Here, the authors report that CTMP, an endogenous inhibitor of Akt, is critical in the neurodegeneration that is associated with stroke. Blockade of CTMP in a stroke model rescues hippocampal neurons.

引用

页码：618 / 626

页数：8

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