The endogenous inhibitor of Akt, CTMP, is critical to ischemia-induced neuronal death

被引：0
|
作者：
Takahiro Miyawaki
Dimitry Ofengeim
Kyung-Min Noh
Adrianna Latuszek-Barrantes
Brian A Hemmings
Antonia Follenzi
R Suzanne Zukin
机构：
[1] Rose F. Kennedy Center,Dominick P. Purpura Department of Neuroscience
[2] Albert Einstein College of Medicine,Department of Neurosurgery
[3] Jichi Medical University,Department of Pathology
[4] Friedrich Miescher Institute for Biomedical Research,undefined
[5] Marion Bessin Liver Research Center,undefined
[6] Albert Einstein College of Medicine,undefined
[7] University of Piemonte Orientale,undefined
[8] School of Medicine,undefined
来源：
Nature Neuroscience | 2009年 / 12卷
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摘要：
Akt signaling has been implicated in a number of diseases, but its role in brain disorders is less clear. Here, the authors report that CTMP, an endogenous inhibitor of Akt, is critical in the neurodegeneration that is associated with stroke. Blockade of CTMP in a stroke model rescues hippocampal neurons.
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页码：618 / 626
页数：8
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