A one-pot microwave-assisted synthesis of pyrido[2,3-d]pyrimidines

被引:0
作者
NÚria Mont
Jordi Teixidó
C. Oliver Kappe
José I. Borrell
机构
[1] Universitat Ramon Llull,Grup d'Enginyeria Molecular, Institut Químic de Sarrià
[2] Karl-Franzens-University Graz,Institute of Chemistry
来源
Molecular Diversity | 2003年 / 7卷
关键词
microwave synthesis; multicomponent reactions; pyrido[2; 3-; ]pyrimidines;
D O I
暂无
中图分类号
学科分类号
摘要
A high yield multicomponent reaction providing multifunctionalized pyrido[2,3-d]pyrimidines with up to four diversity centers in a one-pot microwave-assisted cyclocondensation of α,β-unsaturated esters, amidine systems andmalononitrile (or ethyl cyanoacetate) is described.
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页码:153 / 159
页数:6
相关论文
共 68 条
[1]  
Victory P.(1978)Contribution to the synthesis of glutarimides Afinidad 35 154-158
[2]  
Diago J.(1978)Contribution to the synthesis of glutarimides Afinidad 35 161-165
[3]  
Victory P.(1985)New synthesis of pyrido[2,3-d]pyrimidines. 1. Reaction of 6-alkoxy-5-cyano-3,4-dihydro-2-pyridones with guanidine and cyanamide Heterocycles 23 1135-1141
[4]  
Diago J.(1992)An unequivocal synthesis of 4-amino-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-2,7-diones and 2-amino-3,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-4,7-diones Heterocycles 34 1905-1916
[5]  
Victory P.(1996)Synthesis and biological activity of 7-oxo substituted analogues of 5-deaza-5,6,7,8-tetrahydrofolic acid (5-DATHF) and 5,10-dideaza-5,6,7,8-tetrahydrofolic acid (DDATHF) Collect. Czech. Chem. Commun. 61 901-909
[6]  
Nomen R.(2001)Pneumocystis carinii and Toxoplasma gondii dihydrofolate reductase inhibitors and antitumor agents: synthesis and biological activities of 2,4-diamino-5-methyl-6-[(monosubstituted anilino)methyl]-pyrido[2,3-d]pyrimidines J. Med. Chem. 44 2366-2369
[7]  
Colomina O.(1999)2,4-Diamino-5-deaza-6-substituted pyrido[2,3-d]pyrimidine antifolates as potent and selective nonclassical inhibitors of dihydrofolate reductases J. Med. Chem. 42 2447-2455
[8]  
Garriga M.(1996)Structure-activity relationships for a novel series of pyrido[2,3-d]pyrimidine tyrosine kinase inhibitors J. Med. Chem. 39 1438-1446
[9]  
Crespo A.(1997)',4',5,6]pyrido[2,3-d]pyrimidines as new antiviral agents: Synthesis and biological activity J. Med. Chem. 40 2296-2303
[10]  
Victory P.(2002)Multi-component reactions and evolutionary chemistry Arch. Pharm. 335 289-295