Human T-Cell Leukemia Virus Type 1 Tax and Cellular Transformation

被引：0
作者：
Jean-Marie Peloponese
Takao Kinjo
Kuan-Teh Jeang
机构：
[1] National Institutes of Health,Molecular Virology Section, Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases
来源：
International Journal of Hematology | 2007年 / 86卷
关键词：
Human T-cell leukemia virus 1 (HTLV-1); Adult T-cell leukemia (ATL); Tax; NF-κB; Transformation;
D O I：
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中图分类号：
学科分类号：
摘要：
Infection of T-cells by human T-cell leukemia virus type 1 (HTLV-1) causes a lymphoproliferative malignancy known as adult T-cell leukemia (ATL). ATL is characterized by abnormal lymphocytes, calledflower cells, which have cleaved and convoluted nuclei. Tax, encoded by the HTLV-1 pX region, is a critical nonstructural protein that plays a central role in leuke-mogenesis; however, the mechanisms of HTLV-1 oncogenesis have not been clarified fully. In this review, we summarize current thinking on how Tax may affect ATL leukemogenesis.
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页码：101 / 106
页数：5
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