Matrix-embedded cells control osteoclast formation

被引：0
作者：
Jinhu Xiong
Melda Onal
Robert L Jilka
Robert S Weinstein
Stavros C Manolagas
Charles A O'Brien
机构：
[1] Center for Osteoporosis and Metabolic Bone Diseases,
[2] University of Arkansas for Medical Sciences (UAMS),undefined
[3] Central Arkansas Veterans Healthcare System,undefined
来源：
Nature Medicine | 2011年 / 17卷
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摘要：
To date, the dogma in the field has been that RANKL, an essential cytokine in osteoclast maturation, is released by osteoblasts as a way to coordinate bone growth and bone loss during adult bone remodeling. Now, Hiroshi Takayanagi and colleagues, as well as Charles O'Brien and colleagues, have independently found that osteocytes are the predominant source of RANKL in the adult mouse. As RANKL signaling is a key target in treating osteoporosis, these results have potentially important implications for disease management.
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页码：1235 / 1241
页数：6
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