No association between presenilin 1 (PS1) intronic polymorphism and sporadic Alzheimer's disease in Koreans

被引：0

作者：

K. W. Kim

J. H. Jhoo

K. U. Lee

D. Y. Lee

J. H. Lee

J. Y. Youn

B. J. Lee

J. I. Woo

机构：

[1] Neuroscience Research Institute of Medical Research Center,

[2] Seoul National University,undefined

[3] and Clinical Research Institute of Seoul National University Hospital,undefined

[4] Seoul,undefined

[5] Korea,undefined

[6] Neuroscience Research Institute of Medical Research Center,undefined

[7] Seoul National University,undefined

[8] and Department of Neuropsychiatry,undefined

[9] Seoul National University Hospital,undefined

[10] Seoul,undefined

[11] Korea,undefined

[12] Research Institute of Aging and Physical Culture of Medical Research Center,undefined

[13] Seoul National University,undefined

[14] College of Medicine,undefined

[15] Seoul,undefined

[16] Korea,undefined

[17] Institute of Molecular Biology and Genetics,undefined

[18] Seoul National University,undefined

[19] Seoul,undefined

[20] Korea,undefined

来源：

Journal of Neural Transmission | 2000年 / 107卷

关键词：

Keywords: Alzheimer's disease (AD), presenilin 1 (PS1), alpha-1-antichymotrypsin (ACT), apolipoprotein E (APOE), Koreans.;

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摘要：

To investigate the possible involvement of an intronic polymorphism in the presenilin 1 (PS1) gene and its interactions with the aplolipoprotein E (APOE) or alpha-1 antichymotrypsin (ACT) polymorphisms in the manifestation of AD, we analyzed the PS1, APOE and ACT genotypes of 100 sporadic AD patients and 199 normal elderly controls in Koreans. The genotypic (χ2 = 0.92, df = 2, P > 0.1) and allelic (χ2 = 0.01, df = 1, P > 0.1) frequencies of the PS1 polymorphism in the late- and early-onset sporadic AD patients did not differ from those in the controls. And the occurrence of the APOE ε4 allele and ACT A allele did not influence the distribution of the PS1 intronic polymorphism. The PS1 intronic polymorphism didn't influence the age-at-onset of AD (F = 0.02, df = 2, P > 0.1). In conclusion, the PS1 intronic polymorphism did not modify the risk for sporadic AD, neither independently nor synergistically with the APOE ε4 allele or ACT A allele, in Koreans.

引用

页码：1191 / 1120

页数：-71