Tregs and GvHD prevention by extracorporeal photopheresis: observations from a clinical trial

被引：0
作者：
Roberto Crocchiolo
Clara Cesana
Debora Girgenti
Giambattista Bertani
Claudia Barba
Giuseppa Liga
Ursula Ferri
Lara Crucitti
Giovanni Grillo
Silvano Rossini
Roberto Cairoli
机构：
[1] ASST Grande Ospedale Metropolitano Niguarda,Servizio Di Immunoematologia E Medicina Trasfusionale
[2] Ematologia,undefined
[3] ASST Grande Ospedale Metropolitano Niguarda,undefined
来源：
Experimental Hematology & Oncology | / 10卷
关键词：
Graft-versus-host disease; T regulatory cells; Extracorporeal photopheresis; Allogeneic hematopoietic stem cell transplantation;
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摘要：
The aim of the present study was to evaluate the circulating T regulatory cells (Tregs) in patients undergoing extracorporeal photopheresis (ECP) for the prevention of chronic graft-versus-host disease (GvHD) and to search for any correlation between Tregs counts and chronic GvHD occurrence. Among n = 12 patients with complete longitudinal data, the median cumulative values of absolute peripheral Tregs counts were 21.64 and 63.49 cells/µL for patients who developed chronic GvHD and those who did not develop it, respectively (p = 0.05). The analysis of the median absolute counts of peripheral HLA-DR + Tregs provided similar results, showing that 20% (1 out of 5) and 100% (7 out of 7) of patients with HLA-DR + Tregs values of > 5 cells/µL were in the GvHD and non-GvHD groups, respectively (p = 0.01). In conclusion, the present results support the involvement of Tregs in the prevention of chronic GvHD in patients receiving ECP and suggest Tregs count as a potential biomarker of ECP effectiveness. Future strategies are needed to enhance Tregs expansion and/or activity in conjunction with ECP for an effective chronic GvHD prevention.
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