Neuroprotective Roles of Apelin-13 in Neurological Diseases

被引：0
作者：
Yang Zhang
Weiwei Jiang
Wenjie Sun
Weiming Guo
Beibei Xia
Xiangru Shen
Mingyuan Fu
Teng Wan
Mei Yuan
机构：
[1] University of South China,Department of Neurology, The Second Affiliated Hospital, Hengyang Medical School
[2] Huazhong University of Science and Technology Union Shenzhen Hospital,Department of Neurology
[3] The 6th Affiliated Hospital of Shenzhen University Health Science Center,Department of Sports Medicine
[4] Huazhong University of Science and Technology Union Shenzhen Hospital,Hengyang Medical College
[5] The 6th Affiliated Hospital of Shenzhen University Health Science Center,undefined
[6] University of South China,undefined
来源：
Neurochemical Research | 2023年 / 48卷
关键词：
Apelin-13; Neurological diseases; Neuroinflammation; Apoptosis; Neuroprotection;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Apelin is a natural ligand for the G protein-coupled receptor APJ, and the apelin/APJ system is widely distributed in vivo. Among the apelin family, apelin-13 is the major apelin isoform in the central nervous system and cardiovascular system, and is involved in the regulation of various physiopathological mechanisms such as apoptosis, neuroinflammation, angiogenesis, and oxidative stress. Apelin is currently being extensively studied in the nervous system, and apelin-13 has been shown to be associated with the onset and progression of a variety of neurological disorders, including stroke, neurodegenerative diseases, epilepsy, spinal cord injury (SCI), and psychiatric diseases. This study summarizes the pathophysiological roles of apelin-13 in the development and progression of neurological related diseases.
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页码：1648 / 1662
页数：14
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