A case report: zoledronic acid-induced anterior uveitis

被引：0
作者：
Saadettin Kilickap
Yasemin Ozdamar
M. Kadri Altundag
Omer Dizdar
机构：
[1] Hacettepe University Institute of Oncology,Department of Oncology
[2] Ankara Ulucanlar Eye Research Hospital,Department of Retina
来源：
Medical Oncology | 2008年 / 25卷
关键词：
Zoledronic acid; Cancer; Uveitis; Side effect; Pathogenesis;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Background Bisphosphonates prevent bone loss by binding on active sites of bone remodeling and inhibiting osteoclast-mediated bone resorption. Zoledronic acid is recommended for patients with bone metastases from breast, prostate, and lung cancers. Objective To report a case of anterior uveitis after the infusion of zoledronic acid. Case Summary A breast cancer patient with bone metastasis was admitted with pain, visual loss, hyperemia, and periorbital swelling in her right eye 24 h after the first dose of zoledronic acid. Biomicroscopic anterior segment examination of the right eye showed corneal keratic precipitates, ciliary injection, and moderate amount of cells in anterior chamber. With the diagnosis of right anterior uveitis, topical prednisolone acetate (1%) was started, and her symptoms completely resolved within 1 week. Use of the Naranjo probability scale indicated a probable relationship between uveitis and zoledronic acid therapy in our patient. Discussion Uveitis is a rare complication of zoledronic acid. The mechanism is unclear. Proinflammatory cytokines such as TNF-α and IL-6 may also play a role in pathogenesis of zoledronic acid-related uveitis. Conclusion Zoledronic acid may be associated with inflammatory eye diseases and result in serious ocular damage.
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页码：238 / 240
页数：2
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  • [1] Body JJ(2004)Hypercalcemia of malignancy Semin Nephrol 24 48-54
  • [2] Wardley A(2005)Zoledronic acid significantly improves pain scores and quality of life in breast cancer patients with bone metastases: a randomised, crossover study of community vs hospital bisphosphonate administration Br J Cancer 92 1869-76
  • [3] Davidson N(2005)Bisphosphonates for treatment and prevention of bone metastases J Clin Oncol 23 8219-24
  • [4] Barrett-Lee P(2006)Scleritis complicating zoledronic acid infusion Clin Lymphoma Myeloma 7 145-7
  • [5] Hong A(2006)Acute retinal pigment epitheliitis associated with intravenous bisphosphonate Br J Ophthalmol 90 798-9
  • [6] Michaelson MD(2003)Antitumor effects of bisphosphonates Cancer 97 840-7
  • [7] Smith MR(2003)Bisphosphonates and ocular inflammation N Engl J Med 348 1187-8
  • [8] Benderson D(2002)Bilateral acute anterior uveitis after alendronate Br J Ophthalmol 86 1443-52
  • [9] Karakunnel J(2002)Nongranulomatous anterior uveitis associated with alendronate therapy Invest Clin 43 49-40
  • [10] Kathuria S(2000)Uveitis, an under-recognized adverse effect of pamidronate. Case report and literature review Joint Bone Spine 67 337-2
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