The use of Duloxetine in the treatment of male stress urinary incontinence

被引：12

作者：

Fink K.G. ^{[1
,3
]}

Huber J. ^{[2
]}

Würnschimmel E. ^{[2
]}

Schmeller N.T. ^{[1
]}

机构：

[1] Department of Urology and Andrology, Paracelsus Private Medical University Salzburg, Salzburg

[2] Department of Urology, County Hospital Ried, Ried

[3] Department of Urology and Andrology, Paracelsus Private Medical University, 5020 Salzburg

来源：

Wiener Medizinische Wochenschrift | 2008年 / 158卷 / 3-4期

关键词：

Male; Pharmacologic treatment; Urinary incontinence;

D O I：

10.1007/s10354-007-0494-7

中图分类号：

学科分类号：

摘要：

Stress urinary incontinence (SUI) is a known complication after prostate surgery. To date no pharmacologic treatment is available. Currently Duloxetine, a serotonin and norepinephrine reuptake inhibitor, is available for women with SUI. This study investigates the effect of Duloxetine on men with SUI after prostate surgery. 56 patients were included in our study. 49 after radical prostatectomy and 7 after TURP. All patients were initially treated with pelvic floor exercises. Thereafter 40 mg Duloxetine was administered twice daily. When taking Duloxetine, the average use of incontinence pads decreased from 3.3 to 1.5 per day. 14 patients needed no and 18 a single pad per day. Most patients reported mild and temporary side effects, 13 patients assessed them to be moderate and 9 being severe. The results of this off-label use show that Duloxetine is effective in men with SUI after prostate surgery even if standard pelvic floor exercises have failed. © Springer-Verlag 2007.

引用

页码：116 / 118

页数：2

共 14 条

[1]

Noldus J, Palisaar J, Huland H, Treatment of prostate cancer – The clinical use of radical prostatectomy, EAU Update Series, 1, pp. 16-22, (2003)

[2]

May F, Hartung R, Surgical treatment of BPH: Technique and results, EAU Update Series, 2, pp. 15-23, (2004)

[3]

Wong DT, Bymaster FP, Mayle DA, Reid LR, Krushinski JH, Robertson DW, LY248686, a new inhibitor of serotonin and norepinephrine uptake, Neuropsychopharmacology, 8, pp. 23-33, (1993)

[4]

Thor KB, Katofiasc MA, Effects of Duloxetine, a combined serotonin and norepinephrine reuptake inhibitor, on central neural control of lower urinary tract function in the chloralose-anesthetized female cat, J Pharmacol Exp Ther, 274, pp. 1014-1024, (1995)

[5]

Norton PA, Zinner NR, Yalcin I, Bump RC, Duloxetine versus placebo for the treatment of stress urinary incontinence, Am J Obstet Gynecol, 187, pp. 40-48, (2002)

[6]

Dmochowski RR, Miklos JR, Norton PA, Zinner NR, Yalcin I, Bump RC, Duloxetine versus placebo for the treatment of North American women with stress urinary incontinence, J Urol, 170, pp. 1259-1263, (2003)

[7]

van Kerrebroeck P, Abrams P, Lange R, Duloxetine versus placebo in the treatment of European and Canadian women with stress urinary incontinence, BJOG, 111, pp. 249-257, (2004)

[8]

Zahariou A, Papaioannou P, Kalogirou G, Is HCl duloxetine effective in the management of urinary stress incontinence after radical prostatectomy?, Urol Int, 77, pp. 9-12, (2006)

[9]

Schlenker B, Gratzke Ch, Reich O, Schorsch I, Seitz M, Stief CG, Preliminary results on the off label use of Duloxetine for the treatment of stress incontinence after radical prostatectomy or cystectomy, Eur Urol, 49, pp. 1073-1078, (2006)

[10]

Allahdin S, McKinley CA, Mahmood TA, Tension free vaginal tape: a procedure for all ages, Acta Obstet Gynecol Scand, 83, pp. 937-940, (2004)

← 1 2 →