Management of type 2 diabetes mellitus associated with pituitary gigantism

被引:0
作者
Omar Ali
Swati Banerjee
Daniel F. Kelly
Phillip D. K. Lee
机构
[1] David Geffen School of Medicine at UCLA,Department of Pediatrics
[2] Medical College of Wisconsin,Department of Pediatrics
[3] Children’s Hospital of Central California,Department of Endocrinology
[4] John Wayne Cancer Institute,Endocrinology and Reproductive Health, Clinical Development
[5] EMD Serono Inc,undefined
来源
Pituitary | 2007年 / 10卷
关键词
Pituitary gigantism; Growth hormone; Diabetes mellitus; Diabetic ketoacidosis; Metformin;
D O I
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摘要
Pituitary gigantism, a condition of endogenous growth hormone (GH) hypersecretion prior to epiphyseal closure, is a rare condition. In the adult condition of GH excess, acromegaly, the occurrence of type 2 diabetes mellitus (T2DM) and diabetic ketoacidosis (DKA) have been reported, with resolution following normalization of GH levels. We report the case of a 16-year-old male with pituitary gigantism due to a large invasive suprasellar adenoma who presented with T2DM and DKA. Despite surgical de-bulking, radiotherapy and medical treatment with cabergoline and pegvisomant, GH and insulin-like growth factor-I (IGF-I) levels remained elevated. However, the T2DM and recurrent DKA were successfully managed with metformin and low-dose glargine insulin, respectively. We review the pathophysiology of T2DM and DKA in growth hormone excess and available treatment options.
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页码:359 / 364
页数:5
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