Non-alcoholic fatty liver disease and cardiovascular disease: epidemiological, clinical and pathophysiological evidences

被引:0
作者
Maria Del Ben
Francesco Baratta
Licia Polimeni
Francesco Angelico
机构
[1] La Sapienza Università di Roma,I Clinica Medica, Dipartimento di Medicina Interna e Specialità Mediche
来源
Internal and Emergency Medicine | 2012年 / 7卷
关键词
Non-alcoholic fatty liver disease; Non-alcoholic steatohepatitis; Cardiovascular disease; Metabolic syndrome;
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学科分类号
摘要
Non-alcoholic fatty liver disease is recognized as the most common and emerging chronic liver disease in western countries. The disease has been traditionally interpreted as a possibly progressing condition to liver fibrosis and cirrhosis. However, recently, a large number of publications have demonstrated that people with non-alcoholic fatty liver have an increased chance of developing cardiovascular diseases, which represent the major causes of death in this setting. This association is mainly explained by the atherogenic profile of the metabolic syndrome a condition frequently associated with fatty liver, which may represent its hepatic component. Some studies have also shown an association independent of traditional risk factors or of the clinical features of the metabolic syndrome. In this setting, cardiovascular disease seems to be the consequence of low-grade chronic inflammation and increased oxidative stress. Most studies did not differentiate cardiovascular risk between simple steatosis and non-alcoholic steatohepatitis, although the latter seems to be at higher cardiovascular risk. Few studies have investigated the direct correlation between hepatic inflammation and atherosclerosis. Genetic studies will probably improve the interpretation of the increased cardiovascular risk in patients with fatty liver and no metabolic syndrome.
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页码:291 / 296
页数:5
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