Randomized trial evaluating serial protein C levels in severe sepsis patients treated with variable doses of drotrecogin alfa (activated)

Levy MM(2010)The Surviving Sepsis Campaign: results of an international guideline-based performance improvement program targeting severe sepsis Crit Care Med 38 367-374

Dellinger RP(1991)Protein S and C alterations in acutely ill patients Am J Hematol 36 14-19

Townsend SR(2001)Efficacy and safety of recombinant activated protein C for severe sepsis N Engl J Med 344 699-709

Linde-Zwirble WT(2001)Low levels of protein C are associated with poor outcome in severe sepsis Chest 120 915-922

Marshall JC(2004)Universal changes in biomarkers of coagulation and inflammation occur in patients with severe sepsis, regardless of causative micro-organism Crit Care 8 R82-R90

Bion J(1992)Septic shock, multiple organ failure, and disseminated intravascular coagulation: Compared patterns of antithrombin III, protein C and protein S deficiencies Chest 101 816-823

Schorr C(1993)Time course of hemostatic abnormalities in sepsis and its relation to outcome Chest 103 1536-1542

Artigas A(2000)Prognostic value of protein C concentrations in neutropenic patients at high risk of severe septic complications Crit Care Med 28 2209-2216

Ramsay G(2008)Protein C: a potential biomarker in severe sepsis and a possible tool for monitoring treatment with drotrecogin alfa (activated) Crit Care 12 R45-S228

Beale R(2004)Severe protein C deficiency predicts early death in severe sepsis Crit Care Med 32 S223-23

Levy MM(2010)The Surviving Sepsis Campaign: results of an international guideline-based performance improvement program targeting severe sepsis Crit Care Med 38 367-374

Dellinger RP(1991)Protein S and C alterations in acutely ill patients Am J Hematol 36 14-19

Townsend SR(2001)Efficacy and safety of recombinant activated protein C for severe sepsis N Engl J Med 344 699-709

Linde-Zwirble WT(2001)Low levels of protein C are associated with poor outcome in severe sepsis Chest 120 915-922

Marshall JC(2004)Universal changes in biomarkers of coagulation and inflammation occur in patients with severe sepsis, regardless of causative micro-organism Crit Care 8 R82-R90

Bion J(1992)Septic shock, multiple organ failure, and disseminated intravascular coagulation: Compared patterns of antithrombin III, protein C and protein S deficiencies Chest 101 816-823

Schorr C(1993)Time course of hemostatic abnormalities in sepsis and its relation to outcome Chest 103 1536-1542

Artigas A(2000)Prognostic value of protein C concentrations in neutropenic patients at high risk of severe septic complications Crit Care Med 28 2209-2216

Ramsay G(2008)Protein C: a potential biomarker in severe sepsis and a possible tool for monitoring treatment with drotrecogin alfa (activated) Crit Care 12 R45-S228

Beale R(2004)Severe protein C deficiency predicts early death in severe sepsis Crit Care Med 32 S223-23