The differential effects of IL-1 and TNF-α on proinflammatory cytokine and matrix metalloproteinase expression in human chondrosarcoma cells

被引：0
作者：
J. Shi
E. Schmitt-Talbot
D. A. DiMattia
R. G. Dullea
机构：
[1] Pfizer Global Research and Development,Department of Antibacterial, Immunology, and Inflammation
[2] Pfizer Global Research and Development,Department of Genomic and Proteomic Sciences, MS8118D
[3] Auburn University,3031
来源：
Inflammation Research | 2004年 / 53卷
关键词：
IL-1β; TNF-α; MMP; Chondrocyte; Inflammation;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Objective and design:Interleukin-1 (IL-1), tumor necrosis factor-α (TNF-α), and matrix metalloproteinases (MMPs) play important roles in the pathogenesis of osteoarthritis (OA). In the present study, using Affymetrix oligonucleotide array technology and real-time quantitative RT-PCR we have investigated the molecular mechanisms underlying the differential effect of IL-1 and TNF-α on gene expression in the human chondrosarcoma cell line, SW1353.
引用
收藏
页码：377 / 389
页数：12
相关论文
共 50 条
  • [41] Clinical significance of both tumor and stromal expression of components of the IL-1 and TNF-α signaling pathways in prostate cancer
    Rodriguez-Berriguete, Gonzalo
    Sanchez-Espiridion, Beatriz
    Cansino, Jose R.
    Olmedilla, Gabriel
    Martinez-Onsurbe, Pilar
    Sanchez-Chapado, Manuel
    Paniagua, Ricardo
    Fraile, Benito
    Royuela, Mar
    CYTOKINE, 2013, 64 (02) : 555 - 563
  • [42] Decreased PPAR-γ expression in the conjunctiva and increased expression of TNF-α and IL-1β in the conjunctiva and tear fluid of dry eye mice
    Chen, Yihui
    Zhang, Xiaoyan
    Yang, Ling
    Li, Min
    Li, Bing
    Wang, Weifang
    Sheng, Minjie
    MOLECULAR MEDICINE REPORTS, 2014, 9 (05) : 2015 - 2023
  • [43] Inhibitory Effect of Astragalus Polysaccharides on Lipopolysaccharide-Induced TNF-α and IL-1β Production in THP-1 Cells
    He, Xiaojuan
    Shu, Jun
    Xu, Li
    Lu, Cheng
    Lu, Aiping
    MOLECULES, 2012, 17 (03) : 3155 - 3164
  • [44] Glucosamine Downregulates the IL-1β-Induced Expression of Proinflammatory Cytokine Genes in Human Synovial MH7A Cells by O-GlcNAc Modification-Dependent and - Independent Mechanisms
    Someya, Akimasa
    Ikegami, Takako
    Sakamoto, Koji
    Nagaoka, Isao
    PLOS ONE, 2016, 11 (10):
  • [45] Transient receptor potential vanilloid 1 channels modulate the synaptic effects of TNF-α and of IL-1β in experimental autoimmune encephalomyelitis
    Musumeci, Gabriele
    Grasselli, Giorgio
    Rossi, Silvia
    De Chiara, Valentina
    Musella, Alessandra
    Motta, Caterina
    Studer, Valeria
    Bernardi, Giorgio
    Haji, Nabila
    Sepman, Helena
    Fresegna, Diego
    Maccarrone, Mauro
    Mandolesi, Georgia
    Centonze, Diego
    NEUROBIOLOGY OF DISEASE, 2011, 43 (03) : 669 - 677
  • [46] Young human plasma-derived extracellular vesicles rescue and reactivate IL-1β and TNF-α treated chondrocytes
    Wu, Rongjie
    Xie, Yu
    Peng, Yujie
    Wu, Xiaohu
    Ma, Yuanchen
    Lyu, Feng-Juan
    Zheng, Qiujian
    Deng, Zhantao
    EXPERIMENTAL CELL RESEARCH, 2024, 437 (02)
  • [47] IL-1β promotes the migration of olfactory epithelium neural stem cells through activating matrix metalloproteinase expressions
    Pu, Yu
    Liu, Hongyi
    Xu, He
    Liu, Huanhai
    Cheng, Yin
    Chen, Xiaoping
    Xu, Weihua
    Xu, Yaping
    Fan, Jingping
    PATHOLOGY RESEARCH AND PRACTICE, 2018, 214 (08) : 1210 - 1217
  • [48] The effect of docosahexaenoic acid (DHA) on expression of IL-1β, IL-6, IL-8, and TNF-α in normal and lipopolysaccharide (LPS)-stimulated macrophages
    Solanki, Poonam
    Aminoshariae, Anita
    Jin, Ge
    Montagnese, Thomas A.
    Mickel, Andre
    QUINTESSENCE INTERNATIONAL, 2013, 44 (06): : 392 - 398
  • [49] Cell-specific effects of TNF-α and IL-1β on alkaline phosphatase: implication for syndesmophyte formation and vascular calcification
    Lencel, Philippe
    Delplace, Severine
    Pilet, Paul
    Leterme, Damien
    Miellot, Flore
    Sourice, Sophie
    Caudrillier, Axelle
    Hardouin, Pierre
    Guicheux, Jerome
    Magne, David
    LABORATORY INVESTIGATION, 2011, 91 (10) : 1434 - 1442
  • [50] PXR and NF-κB correlate with the inducing effects of IL-1β and TNF-α on ABCG2 expression in breast cancer cell lines
    Malekshah, Obeid M.
    Iage, Hermann
    Bahrami, Ahmad Reza
    Afshari, Jalil Tavakol
    Behravan, Javad
    EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2012, 47 (02) : 474 - 480
12345