Development of hematopoietic cells from embryonic stem cells

被引：0
作者：
Akira Suzuki
Toru Nakano
机构：
[1] Osaka University,Department of Molecular Cell Biology, Research Institute for Microbial Diseases
[2] Osaka University,Department of Molecular Cell Biology, Research Institute for Microbial Diseases
来源：
International Journal of Hematology | 2001年 / 73卷
关键词：
Embryonic stem cell; Cell differentiation; Hematopoiesis; Cell therapy;
D O I：
暂无
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学科分类号：
摘要：
Embryonic stem cells are pluripotent stem cells that can differentiate into all somatic cell lineages and germ lineage cells in vivo. In vitro differentiation capacity of the cells is rather limited compared with the in vivo pluripotency. However, differentiation into hematopoietic lineages is easily obtained, and it is a powerful tool to investigate hematopoietic development and differentiation. In this article, we describe a differentiation induction method that we established, theOP9 system, a unique method using the macrophage colony-stimulating factor-deficient stromal cell lineOP9. The utility of theOP9 system includes hematopoietic development, differentiation,B-cell formation, osteoclast formation, and so on. The usefulness and limits of embryonic stem cell-derived hematopoietic cells in cell therapy are also discussed.
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页码：1 / 5
页数：4
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