Cyclooxygenase in Cancer Prevention and Treatments for Actinic Keratosis

被引：0
作者：
Gareth J. Thomas
Colin A. Morton
机构：
[1] University of Southampton,Cancer Sciences Unit, Faculty of Medicine
[2] NHS Forth Valley,undefined
来源：
Dermatology and Therapy | 2017年 / 7卷
关键词：
Actinic keratosis; Cancer prevention; Cyclooxygenase; Non-steroidal anti-inflammatory drugs; Prognosis; Treatment;
D O I：
暂无
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学科分类号：
摘要：
Non-steroidal anti-inflammatory drugs (NSAIDs) are a chemically diverse class of drugs that target the cyclooxygenase (COX) pathway and have anti-inflammatory, analgesic, and antipyretic properties. Elevated expression of COX-2 has been associated with tumor progression in skin cancer through multiple mechanisms. We present evidence for a chemoprotective effect of NSAIDs and discuss potential mechanisms of action of COX-2 in cancer. We also discuss the challenges associated with the treatment of actinic keratosis and the factors that should be taken into consideration when selecting a treatment regimen. A range of treatments are reviewed, with an emphasis on combination therapies.
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页码：21 / 29
页数：8
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