Antiphospholipid syndrome

被引：0
作者：
Gerard Espinosa
Ricard Cervera
机构：
[1] Institut Clínic de Medicina i Dermatologia,Department of Autoimmune Diseases
[2] Hospital Clínic,undefined
来源：
Arthritis Research & Therapy | / 10卷
关键词：
Systemic Lupus Erythematosus; Systemic Lupus Erythematosus Patient; Tissue Factor; Thrombotic Thrombocytopenic Purpura; Fetal Loss;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Antiphospholipid syndrome is diagnosed when arterial or venous thrombosis or recurrent miscarriages occur in a person in whom laboratory tests for antiphospholipid antibodies (anticardiolipin antibodies and/or lupus anticoagulant and/or anti-beta 2-glycoprotein I) are positive. Despite the strong association between antiphospho-lipid antibodies and thrombosis, their pathogenic role in the development of thrombosis has not been fully elucidated. Novel mechanisms involving both the complement pathway and micro-particles have been described. The knowledge of these new pathogenic approaches might identify novel therapeutic targets and therefore may improve the management of these patients.
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