Both conditional ablation and overexpression of E2 SUMO-conjugating enzyme (UBC9) in mouse pancreatic beta cells result in impaired beta cell function

[11] Plummer G(2011)SUMOylation regulates insulin exocytosis downstream of secretory granule docking in rodents and humans Diabetes 60 838-847

[12] Pandey D(2013)SUMOylation of pancreatic glucokinase regulates its cellular stability and activity J Biol Chem 288 5951-5962

[13] Chen F(2015)Isocitrate-to-SENP1 signaling amplifies insulin secretion and rescues dysfunctional beta cells J Clin Investig 125 3847-3860

[14] Patel A(2012)SUMO downregulates GLP-1-stimulated cAMP generation and insulin secretion Am J Phys Endocrinol Metab 302 E714-E723

[15] Guo D(2015)Chronic hyperglycemia downregulates GLP-1 receptor signaling in pancreatic beta-cells via protein kinase A Mol Metab 4 265-276

[16] Han J(2017)SUMOylation and calcium control syntaxin-1A and secretagogin sequestration by tomosyn to regulate insulin exocytosis in human β cells Sci Rep 7 248-48

[17] Adam BL(2013)Beneficial effects of inhibition of soluble epoxide hydrolase on glucose homeostasis and islet damage in a streptozotocin-induced diabetic mouse model Prostaglandins & Other Lipid Mediators 104–105 42-3395

[18] Kishi A(2016)Loss of Mbd2 protects mice against high fat diet-induced obesity and insulin resistance by regulating the homeostasis of energy storage and expenditure Diabetes 65 3384-71

[19] Nakamura T(2008)Comparative analysis of the islet proteome between NOD/Lt and ALR/Lt mice Ann N Y Acad Sci 1150 68-1984

[20] Nishio Y(2016)HMGB1 exacerbates bronchiolitis obliterans syndrome via RAGE/NF-kappaB/HPSE signaling to enhance latent TGF-beta release from ECM Am J Transl Res 8 1971-2127

[11] Plummer G(2011)SUMOylation regulates insulin exocytosis downstream of secretory granule docking in rodents and humans Diabetes 60 838-847

[12] Pandey D(2013)SUMOylation of pancreatic glucokinase regulates its cellular stability and activity J Biol Chem 288 5951-5962

[13] Chen F(2015)Isocitrate-to-SENP1 signaling amplifies insulin secretion and rescues dysfunctional beta cells J Clin Investig 125 3847-3860

[14] Patel A(2012)SUMO downregulates GLP-1-stimulated cAMP generation and insulin secretion Am J Phys Endocrinol Metab 302 E714-E723

[15] Guo D(2015)Chronic hyperglycemia downregulates GLP-1 receptor signaling in pancreatic beta-cells via protein kinase A Mol Metab 4 265-276

[16] Han J(2017)SUMOylation and calcium control syntaxin-1A and secretagogin sequestration by tomosyn to regulate insulin exocytosis in human β cells Sci Rep 7 248-48

[17] Adam BL(2013)Beneficial effects of inhibition of soluble epoxide hydrolase on glucose homeostasis and islet damage in a streptozotocin-induced diabetic mouse model Prostaglandins & Other Lipid Mediators 104–105 42-3395

[18] Kishi A(2016)Loss of Mbd2 protects mice against high fat diet-induced obesity and insulin resistance by regulating the homeostasis of energy storage and expenditure Diabetes 65 3384-71

[19] Nakamura T(2008)Comparative analysis of the islet proteome between NOD/Lt and ALR/Lt mice Ann N Y Acad Sci 1150 68-1984

[20] Nishio Y(2016)HMGB1 exacerbates bronchiolitis obliterans syndrome via RAGE/NF-kappaB/HPSE signaling to enhance latent TGF-beta release from ECM Am J Transl Res 8 1971-2127