Both conditional ablation and overexpression of E2 SUMO-conjugating enzyme (UBC9) in mouse pancreatic beta cells result in impaired beta cell function

[1] Yang P(2014)Sumoylation modulates oxidative stress relevant to the viability and functionality of pancreatic beta cells Am J Transl Res 6 353-360

[2] Hu S(2013)Sumoylation: a regulatory protein modification in health and disease Annu Rev Biochem 82 357-385

[3] Yang F(2005)SUMO wrestling with type 1 diabetes J Mol Med (Berlin, Germany) 83 504-513

[4] Flotho A(2014)SUMOylation protects against IL-1beta-induced apoptosis in INS-1 832/13 cells and human islets Am J Phys Endocrinol Metab 307 E664-E673

[5] Melchior F(2011)SUMO1 negatively regulates reactive oxygen species production from NADPH oxidases Arterioscler Thromb Vasc Biol 31 1634-1642

[6] Li M(2005)Proteomic analysis of SUMO4 substrates in HEK293 cells under serum starvation-induced stress Biochem Biophys Res Commun 337 1308-1318

[7] Guo D(2003)Sumoylation of Pdx1 is associated with its nuclear localization and insulin gene activation Am J Phys Endocrinol Metab 284 E830-E840

[8] Isales CM(2006)Synergy of glucose and growth hormone signalling in islet cells through ICA512 and STAT5 Nat Cell Biol 8 435-445

[9] Hajmrle C(2009)Sumoylation regulates the transcriptional activity of MafA in pancreatic beta cells J Biol Chem 284 3117-3124

[10] Ferdaoussi M(2009)SUMOylation regulates Kv2.1 and modulates pancreatic beta-cell excitability J Cell Sci 122 775-779

[1] Yang P(2014)Sumoylation modulates oxidative stress relevant to the viability and functionality of pancreatic beta cells Am J Transl Res 6 353-360

[2] Hu S(2013)Sumoylation: a regulatory protein modification in health and disease Annu Rev Biochem 82 357-385

[3] Yang F(2005)SUMO wrestling with type 1 diabetes J Mol Med (Berlin, Germany) 83 504-513

[4] Flotho A(2014)SUMOylation protects against IL-1beta-induced apoptosis in INS-1 832/13 cells and human islets Am J Phys Endocrinol Metab 307 E664-E673

[5] Melchior F(2011)SUMO1 negatively regulates reactive oxygen species production from NADPH oxidases Arterioscler Thromb Vasc Biol 31 1634-1642

[6] Li M(2005)Proteomic analysis of SUMO4 substrates in HEK293 cells under serum starvation-induced stress Biochem Biophys Res Commun 337 1308-1318

[7] Guo D(2003)Sumoylation of Pdx1 is associated with its nuclear localization and insulin gene activation Am J Phys Endocrinol Metab 284 E830-E840

[8] Isales CM(2006)Synergy of glucose and growth hormone signalling in islet cells through ICA512 and STAT5 Nat Cell Biol 8 435-445

[9] Hajmrle C(2009)Sumoylation regulates the transcriptional activity of MafA in pancreatic beta cells J Biol Chem 284 3117-3124

[10] Ferdaoussi M(2009)SUMOylation regulates Kv2.1 and modulates pancreatic beta-cell excitability J Cell Sci 122 775-779