A non-enzymatic glucose sensor based on NiO nanoparticles/functionalized SBA 15/MWCNT-modified carbon paste electrode

A simple non-enzymatic glucose sensor was proposed based on electrodeposited NiO nanoparticles (NiO NPs) onto a functionalized Santa Barbara Amorphous (SBA 15) material/multiwall carbon nanotube (MWCNTs)-modified carbon paste electrode (CPE). NiO NPs deposited on the modified electrode showed good catalytic activities toward glucose oxidation in alkaline media. Scanning electron microscopy (SEM) studies demonstrated that large amounts of NiO nanoparticles can be deposited on the surface of the modified electrode. In addition, NiO NPs/functionalized SBA 15/MWCNT-modified CPE was also characterized by electrochemical methods including cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS). The amperometric signals were linearly proportional to glucose concentration in the range of 0.06–400 μM with a detection limit of 0.023 μM, which was comparable with previously reported glucose sensors. Moreover, the modified CPE was successfully applied for the detection of glucose in real samples. The disposable amperometric sensor in this study showed a rapid and highly sensitive response to glucose which might find promising applications in medical applications and disease diagnosis.