A novel and efficient synthesis of 3-iodo substituted 1,8-naphthyridines by electrophilic cyclization of 2-amino nicotinaldehyde and their antimicrobial activity

被引：0
|
作者：
B. Sakram
K. Ashok
S. Rambabu
B. Sonyanaik
D. Ravi
机构：
[1] Osmania University,Department of Chemistry
来源：
Russian Journal of General Chemistry | 2017年 / 87卷
关键词：
2-aminonicotinaldehyde; electrophilic cyclization; iodine; 1,8-naphthyridine; antimicrobial activity;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Synthesis of substituted 1,8-naphthyridines based on 2-aminonicotinaldehyde under mild conditions is studied. Out of three electrophilic iodine sources (I2, NIS, and ICl) studied, I2 was determined to act most efficiently in the process. High overall yields were achieved for aliphatic substitution at the reaction center. All compounds were evaluated for antibacterial activity (Staphylococus aureus, Bacillus subtilis, Escherichia coli, and Klebsiella pneumonia) and anti-fungi activity (Aspergillus flavus and Fusarium oxysporum).
引用
收藏
页码：1794 / 1799
页数：5
相关论文
共 50 条
  • [1] A novel and efficient synthesis of 3-iodo substituted 1,8-naphthyridines by electrophilic cyclization of 2-amino nicotinaldehyde and their antimicrobial activity
    Sakram, B.
    Ashok, K.
    Rambabu, S.
    Sonyanaik, B.
    Ravi, D.
    RUSSIAN JOURNAL OF GENERAL CHEMISTRY, 2017, 87 (08) : 1794 - 1799
  • [2] Synthesis and Antimicrobial Activity of Pyrazole Derivatives of 2-Cyclopropyl-1,8-naphthyridines
    Narender, Atmakuri
    Kumar, Mattepally Ranadheer
    Laxminarayana, Eppkayalaya
    Chary, Maringanti Thirumala
    ASIAN JOURNAL OF CHEMISTRY, 2009, 21 (09) : 6885 - 6903
  • [3] Green design, synthesis of novel 2-methoxy-3-aryl-1,8-naphthyridines and their biological and molecular docking study
    Ravi, Dharavath
    Sonyanaik, Banoth
    Sakram, Boda
    RESULTS IN CHEMISTRY, 2022, 4
  • [4] SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF NOVEL 2-AMINO-3-CYANOPYRIDINES
    Bharathi, Y. Siva
    Apparao, T.
    Naidu, S. Venkata
    HETEROCYCLIC LETTERS, 2011, 1 (02): : 146 - 152
  • [5] A Simple “Green” Synthesis of Novel Bis(3-aryl-1,8-naphthyridin-2-yl)sulfanes and 2-(Methylthio)-3-aryl-1,8-naphthyridines under Microwave Irradiation and Conventional Conditions
    D. Ravi
    K. Ashok
    S. Rambabu
    B. Sakram
    P. Shyam
    Russian Journal of General Chemistry, 2018, 88 : 1232 - 1237
  • [6] A Simple "Green" Synthesis of Novel Bis(3-aryl-1,8-naphthyridin-2-yl)sulfanes and 2-(Methylthio)-3-aryl-1,8-naphthyridines under Microwave Irradiation and Conventional Conditions
    Ravi, D.
    Ashok, K.
    Rambabu, S.
    Sakram, B.
    Shyam, P.
    RUSSIAN JOURNAL OF GENERAL CHEMISTRY, 2018, 88 (06) : 1232 - 1237
  • [7] Electrophilic cyclization of homopropargyl tellurides: Synthesis and supramolecular structures of 2-aryl-3-iodo-1-phenyl-tellurophenium iodides and polyiodides
    Cargnelutti, Roberta
    Lang, Ernesto S.
    Back, Davi F.
    Schumacher, Ricardo F.
    POLYHEDRON, 2014, 73 : 45 - 50
  • [8] Electrophilic cyclization of 4-thio-but-2-yn-1-ols via 1,2-migration of the thio group: efficient synthesis of 2,4-dihalo-3-thio-substituted furans
    Zhou, Hongwei
    Yao, Jinzhong
    Liu, Guoliang
    TETRAHEDRON LETTERS, 2008, 49 (02) : 226 - 228
  • [9] Synthesis and antimicrobial activity of 1-furyl-3-(substituted phenyl)-2-propene-1-one
    Bhendkar, AH
    Doshi, AG
    Raut, AW
    ASIAN JOURNAL OF CHEMISTRY, 2004, 16 (01) : 265 - 268
  • [10] A novel synthesis and antimicrobial activity of 1-[(Substituted-phenyl) sulfonyl]pyrrolidin-2-ones
    Zareef, Muhammad
    Iqbal, Rashid
    Arfan, Muhammad
    JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2008, 23 (01) : 82 - 86
12345