Synthesis and activity of a potent α-glucosidase inhibitor, (1R, 6R, 8S)-cis-1,6-dihydroxypyrrolizidine, and its isomer

被引：0

作者：

Kyeong-Eun Jung

Yong-Koo Kang

Dong Jin Kim

Sang Woo Park

机构：

[1] Korea Institute of Science and Technology,

来源：

Archives of Pharmacal Research | 1997年 / 20卷

关键词：

a-glucosidase inhibitor; swainsonine; pyrrolizidine derivatives;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

The synthesis ofcis- and trans-1,6-dihydroxypyrrolizidine starting fromtrans-4-hydroxyl-L-proline and their evaluation as glycosidase inhibitors are reported. Thecis-isomer was found to be a potent inhibitor against α-glucosidase and showed weak inhibitory effect against other glycosidases. Thetrans-isomer exhibited weak inhibitions of b-glucosidase and amyloglucosidase and poor inhibition of other glycosidases.

引用

页码：346 / 350

页数：4

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