Synthesis and activity of a potent α-glucosidase inhibitor, (1R, 6R, 8S)-cis-1,6-dihydroxypyrrolizidine, and its isomer

被引：0
|
作者：
Kyeong-Eun Jung
Yong-Koo Kang
Dong Jin Kim
Sang Woo Park
机构：
[1] Korea Institute of Science and Technology,
来源：
Archives of Pharmacal Research | 1997年 / 20卷
关键词：
a-glucosidase inhibitor; swainsonine; pyrrolizidine derivatives;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The synthesis ofcis- and trans-1,6-dihydroxypyrrolizidine starting fromtrans-4-hydroxyl-L-proline and their evaluation as glycosidase inhibitors are reported. Thecis-isomer was found to be a potent inhibitor against α-glucosidase and showed weak inhibitory effect against other glycosidases. Thetrans-isomer exhibited weak inhibitions of b-glucosidase and amyloglucosidase and poor inhibition of other glycosidases.
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页码：346 / 350
页数：4
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