Synthesis and activity of a potent α-glucosidase inhibitor, (1R, 6R, 8S)-cis-1,6-dihydroxypyrrolizidine, and its isomer

被引:0
|
作者
Kyeong-Eun Jung
Yong-Koo Kang
Dong Jin Kim
Sang Woo Park
机构
[1] Korea Institute of Science and Technology,
来源
Archives of Pharmacal Research | 1997年 / 20卷
关键词
a-glucosidase inhibitor; swainsonine; pyrrolizidine derivatives;
D O I
暂无
中图分类号
学科分类号
摘要
The synthesis ofcis- and trans-1,6-dihydroxypyrrolizidine starting fromtrans-4-hydroxyl-L-proline and their evaluation as glycosidase inhibitors are reported. Thecis-isomer was found to be a potent inhibitor against α-glucosidase and showed weak inhibitory effect against other glycosidases. Thetrans-isomer exhibited weak inhibitions of b-glucosidase and amyloglucosidase and poor inhibition of other glycosidases.
引用
收藏
页码:346 / 350
页数:4
相关论文
共 50 条