A comparative study on oxidative stress and antioxidant status in ischemic stroke patients with and without diabetes

被引：7
作者：
D'Souza B. [1 ,2 ]
D'Souza V. [1 ,2 ]
Sowmya S. [1 ,2 ]
Seema G. [1 ,2 ]
Hemalatha C.N. [1 ,2 ]
Anu M. [1 ,2 ]
Sajana G. [1 ,2 ]
机构：
[1] Department of Biochemistry, Centre for Basic Sciences, Kasturba Medical College, Mangalore
[2] Department of Biochemistry, Centre for Basic Sciences, Kasturba Medical College, Mangalore
来源：
Indian Journal of Clinical Biochemistry | 2008年 / 23卷 / 3期
关键词：
Antioxidants; Ischemic stroke; Lipid peroxidation;
D O I：
10.1007/s12291-008-0049-8
中图分类号：
学科分类号：
摘要：
The study was conducted to find out the extent of lipid peroxidation and antioxidant status in ischemic stroke patients (ISPs) with and without diabetes. Malondialdehyde (MDA) was studied as a marker of lipid peroxidation. Glutathione (GSH), uric acid and ceruloplasmin were estimated to study the antioxidant potential of ISPs. Significantly higher levels of MDA were found in both the groups of ISPs and the increase in MDA was more in ISPs without diabetes. GSH levels were decreased significantly in both the groups of ISPs and maximum decline was found in ISPs with diabetes. Uric acid levels were significantly increased in both the groups of ISPs. Ceruloplasmin levels were increased significantly in ISPs without diabetes, whereas its levels were slightly decreased in ISPs with diabetes. A negative correlation was found between MDA and the antioxidants GSH, uric acid and ceruloplasmin in ISPs with diabetes. This study suggests that there is an association between ischemic stroke and increased oxidative stress and the antioxidant potential is impaired in both the groups of ISPs with and without diabetes.
引用
收藏
页码：218 / 222
页数：4
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