A comparative study on oxidative stress and antioxidant status in ischemic stroke patients with and without diabetes

被引：7
|
作者：
D'Souza B. [1 ,2 ]
D'Souza V. [1 ,2 ]
Sowmya S. [1 ,2 ]
Seema G. [1 ,2 ]
Hemalatha C.N. [1 ,2 ]
Anu M. [1 ,2 ]
Sajana G. [1 ,2 ]
机构：
[1] Department of Biochemistry, Centre for Basic Sciences, Kasturba Medical College, Mangalore
[2] Department of Biochemistry, Centre for Basic Sciences, Kasturba Medical College, Mangalore
来源：
Indian Journal of Clinical Biochemistry | 2008年 / 23卷 / 3期
关键词：
Antioxidants; Ischemic stroke; Lipid peroxidation;
D O I：
10.1007/s12291-008-0049-8
中图分类号：
学科分类号：
摘要：
The study was conducted to find out the extent of lipid peroxidation and antioxidant status in ischemic stroke patients (ISPs) with and without diabetes. Malondialdehyde (MDA) was studied as a marker of lipid peroxidation. Glutathione (GSH), uric acid and ceruloplasmin were estimated to study the antioxidant potential of ISPs. Significantly higher levels of MDA were found in both the groups of ISPs and the increase in MDA was more in ISPs without diabetes. GSH levels were decreased significantly in both the groups of ISPs and maximum decline was found in ISPs with diabetes. Uric acid levels were significantly increased in both the groups of ISPs. Ceruloplasmin levels were increased significantly in ISPs without diabetes, whereas its levels were slightly decreased in ISPs with diabetes. A negative correlation was found between MDA and the antioxidants GSH, uric acid and ceruloplasmin in ISPs with diabetes. This study suggests that there is an association between ischemic stroke and increased oxidative stress and the antioxidant potential is impaired in both the groups of ISPs with and without diabetes.
引用
收藏
页码：218 / 222
页数：4
相关论文
共 50 条
  • [1] TOTAL OXIDATIVE STRESS, TOTAL ANTIOXIDANT STATUS AND ERYTHROCYTES STATUS IN PATIENTS WITH ACUTE ISCHEMIC STROKE
    Goekdemir, Guel Sahika
    Gokdemir, Mehmet Tahir
    Karakilcik, Ali Ziya
    ACTA MEDICA MEDITERRANEA, 2017, 33 (01): : 157 - 163
  • [2] Oxidative stress and oxygen status in ischemic stroke
    Skvortsova, V. I.
    Nartsissov, Ya. R.
    Bodykhov, M. K.
    Kichuck, I. V.
    Pryanikova, N. A.
    Gudkova, Yu. V.
    Soldatenkova, T. D.
    Kondrashova, T. T.
    Kalinina, E. V.
    Novichkova, M. D.
    Shutyeva, A. B.
    Kerbikov, O. B.
    ZHURNAL NEVROLOGII I PSIKHIATRII IMENI S S KORSAKOVA, 2007, 107 (01) : 30 - 36
  • [3] Oxidative stress and paraoxonase 1 status in acute ischemic stroke patients
    Kotur-Stevuljevic, Jelena
    Bogavac-Stanojevic, Natasa
    Jelic-Ivanovic, Zorana
    Stefanovic, Aleksandra
    Gojkovic, Tamara
    Joksic, Jelena
    Sopic, Miron
    Gulan, Brankica
    Janac, Jelena
    Milosevic, Sanja
    ATHEROSCLEROSIS, 2015, 241 (01) : 192 - 198
  • [4] Evaluation of prognosis with total oxidant/antioxidant status and some oxidative stress parameters in patients with acute ischemic stroke
    Ada, S.
    FEBS JOURNAL, 2016, 283 : 322 - 322
  • [5] Serum antioxidant enzymes activities and oxidative stress levels in patients with acute ischemic stroke: influence on neurological status and outcome
    Milanlioglu, Aysel
    Aslan, Mehmet
    Ozkol, Halil
    Cilingir, Vedat
    Aydin, Mehmet Nuri
    Karadas, Sevdegul
    WIENER KLINISCHE WOCHENSCHRIFT, 2016, 128 (5-6) : 169 - 174
  • [6] Serum antioxidant enzymes activities and oxidative stress levels in patients with acute ischemic stroke: influence on neurological status and outcome
    Aysel Milanlioglu
    Mehmet Aslan
    Halil Ozkol
    Vedat Çilingir
    Mehmet Nuri Aydın
    Sevdegül Karadas
    Wiener klinische Wochenschrift, 2016, 128 : 169 - 174
  • [7] Biomarkers of diabetes-associated oxidative stress and antioxidant status in young diabetic patients with or without subclinical complications
    Martín-Gallán, P
    Carrascosa, A
    Gussinyé, M
    Domínguez, C
    FREE RADICAL BIOLOGY AND MEDICINE, 2003, 34 (12) : 1563 - 1574
  • [8] Oxidative Stress and Total Antioxidant Capacity in Diabetic and Nondiabetic Acute Ischemic Stroke Patients
    Guldiken, Baburhan
    Demir, Muzaffer
    Guldiken, Sibel
    Turgut, Nilda
    Turgut, Burhan
    Tugrul, Armagan
    CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS, 2009, 15 (06) : 695 - 700
  • [9] Oxidative and nitrosative stress in patients with ischemic stroke
    Dogan, Ozlem
    Kisa, Ucler
    Erdemoglu, Ali Kemal
    Kacmaz, Murat
    Caglayan, Osman
    Kurku, Huseyin
    JOURNAL OF LABORATORY MEDICINE, 2018, 42 (05) : 195 - 200
  • [10] Oxidative stress and antioxidant capacity in patients with chronic pancreatitis with and without diabetes mellitus
    Namrata Singh
    Payal Bhardwaj
    Ravinder M Pandey
    Anoop Saraya
    Indian Journal of Gastroenterology, 2012, 31 (5) : 226 - 231
12345