Clinical application of mesenchymal stem cell in regenerative medicine: a narrative review

被引：0
作者：
Ria Margiana
Alexander Markov
Angelina O. Zekiy
Mohammed Ubaid Hamza
Khalid A. Al-Dabbagh
Sura Hasan Al-Zubaidi
Noora M. Hameed
Irshad Ahmad
R. Sivaraman
Hamzah H. Kzar
Moaed E. Al-Gazally
Yasser Fakri Mustafa
Homayoon Siahmansouri
机构：
[1] Universitas Indonesia,Department of Anatomy, Faculty of Medicine
[2] Universitas Indonesia,Master’s Programme Biomedical Sciences, Faculty of Medicine
[3] Dr. Soetomo General Academic Hospital,Department of Prosthetic Dentistry
[4] Tyumen State Medical University,Medical Technical College
[5] Tyumen Industrial University,Department of Dentistry
[6] I.M. Sechenov First Moscow State Medical University (Sechenov University),Anesthesia Techniques Department
[7] Al-Farahidi University,Anesthesia Techniques
[8] Al-Hadba University College,Department of Medical Rehabilitation Sciences, College of Applied Medical Sciences
[9] Al-Mustaqbal University College,Department of Mathematics, Dwaraka Doss Goverdhan Doss Vaishnav College, Arumbakkam
[10] Al–Nisour University College,Veterinary Medicine College
[11] King Khalid University,College of Medicine
[12] University of Madras,Department of Pharmaceutical Chemistry, College of Pharmacy
[13] Al-Qasim Green University,Department of Immunology, Faculty of Medicine
[14] University of Al-Ameed,undefined
[15] University of Mosul,undefined
[16] Tabriz University of Medical Sciences,undefined
来源：
Stem Cell Research & Therapy | / 13卷
关键词：
Mesenchymal stromal cell; Regenerative medicine; Stem cell therapy; Tissue regeneration; Cell therapy;
D O I：
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摘要：
The multipotency property of mesenchymal stem cells (MSCs) has attained worldwide consideration because of their immense potential for immunomodulation and their therapeutic function in tissue regeneration. MSCs can migrate to tissue injury areas to contribute to immune modulation, secrete anti-inflammatory cytokines and hide themselves from the immune system. Certainly, various investigations have revealed anti-inflammatory, anti-aging, reconstruction, and wound healing potentials of MSCs in many in vitro and in vivo models. Moreover, current progresses in the field of MSCs biology have facilitated the progress of particular guidelines and quality control approaches, which eventually lead to clinical application of MSCs. In this literature, we provided a brief overview of immunoregulatory characteristics and immunosuppressive activities of MSCs. In addition, we discussed the enhancement, utilization, and therapeutic responses of MSCs in neural, liver, kidney, bone, heart diseases, and wound healing.
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