Association of IL-10, IL-4, and IL-28B gene polymorphisms with spontaneous clearance of hepatitis C virus in a population from Rio de Janeiro

被引：23

作者：

Juliene Antonio Ramos

Rosane Silva

Luísa Hoffmann

Ana Lucia Araújo Ramos

Pedro Hernan Cabello

Turán Péter Ürményi

Cristiane Alves Villella-Nogueira

Lia Lewis-Ximenez

Edson Rondinelli

机构：

[1] Instituto de Biofísica Carlos Chagas Filho, Universidade Federal Do Rio de Janeiro, Rio de Janeiro

[2] Instituto Federal de Educação Ciência e Tecnologia Do Rio de Janeiro, Rio de Janeiro

[3] Serviço de Hepatologia, Hospital Universitário Clementino Fraga Filho, Universidade Federal Do Rio de Janeiro, Rio de Janeiro

[4] Departamento de Clínica Médica, Faculdade de Medicina, Universidade Federal Do Rio de Janeiro, Rio de Janeiro

[5] Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro

[6] Instituto Nacional Para Pesquisa Translacional em Saude e Ambiente Na Regiao Amazonica, Conselho Nacional de Desenvolvimento Científico e Tecnológico/MCT, Rio de Janeiro

来源：

BMC Research Notes | / 5卷 / 1期

基金：

美国国家卫生研究院;

关键词：

Acute hepatitis C; Chronic hepatitis C; Cytokines; Gene polymorphism; HCV; Spontaneous viral clearance;

D O I：

10.1186/1756-0500-5-508

中图分类号：

学科分类号：

摘要：

Background: Cytokines play an important role in the regulation of the immune response. In hepatitis C virus (HCV) infection, cytokine levels may influence the outcome of acute HCV infection. Polymorphisms in cytokine genes have been associated to different expression levels in response to infection. This study was carried out to investigate the association of several cytokine gene polymorphisms with disease outcome in HCV-infected patients. Findings. Patients with chronic or spontaneously resolved HCV infection were included in a cross-sectional study. A comparative analysis was performed between the groups regarding frequency distribution of the following cytokines gene polymorphisms: IL-10 (1082 A/G; -819T/C; -592 A/C), IL-4 (+33C/T), IFN-γ (+874T/A), TNF-α (238G/A and 308G/A) and IL-28B (rs12979860 C/T and rs8099917 T/G). Results:Eighteen patients with spontaneous viral clearance and 161 with chronic HCV infection were included. In the comparative analysis, the GG genotype of the IL-10 polymorphism -1082A/G was more frequent in patients with spontaneous viral clearance when compared to patients with chronic HCV (41.2% vs 6.2%; p = 0.001). This association was also found for the CC genotype of the IL-4 polymorphism +33C/T (72.2% vs 36.7%; p = 0.017) and the CC and TT genotypes of the IL-28B polymorphisms rs 12979860 and rs 8099917 (88.9% vs 30.3%; p<0.001 and 88.9% vs 49.6%; p = 0.002). The IL10 (A-1082G) and IL-28B (Crs12979860T) gene polymorphisms showed odds ratios of 12.848 and 11.077, respectively, and thus may have a greater influence on HCV spontaneous viral clearance. The IFN-γ (+874T/A), TNF-α (238G/A and 308G/A) polymorphisms did not show significant association with spontaneous viral clearance or chronicity. Conclusion: The G allele for IL-10 (1082 A/G), the C allele for IL-4 (+3 C/T) and the C and T alleles for IL-28B (rs12979860 and rs8099917, respectively) are associated with spontaneous viral clearance in hepatitis C infection. © 2012 Ramos et al.; licensee BioMed Central Ltd.

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