Lifelong environmental enrichment in rats: impact on emotional behavior, spatial memory vividness, and cholinergic neurons over the lifespan

被引：0
作者：
Hayat Harati
Alexandra Barbelivien
Karine Herbeaux
Marc-Antoine Muller
Michel Engeln
Christian Kelche
Jean-Christophe Cassel
Monique Majchrzak
机构：
[1] Université de Strasbourg,Laboratoire d’Imagerie et de Neurosciences Cognitives, UMR 7237 CNRS
来源：
AGE | 2013年 / 35卷
关键词：
Acetylcholine; Aging; Anxiety; Basal forebrain; Enriched environment; Recent and remote memory; Striatum;
D O I：
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学科分类号：
摘要：
We assessed lifelong environmental enrichment effects on possible age-related modifications in emotional behaviors, spatial memory acquisition, retrieval of recent and remote spatial memory, and cholinergic forebrain systems. At the age of 1 month, Long–Evans female rats were placed in standard or enriched rearing conditions and tested after 3 (young), 12 (middle-aged), or 24 (aged) months. Environmental enrichment decreased the reactivity to stressful situations regardless of age. In the water maze test, it delayed the onset of learning deficits and prevented age-dependent spatial learning and recent memory retrieval alterations. Remote memory retrieval, which was altered independently of age under standard rearing conditions, was rescued by enrichment in young and middle-aged, but unfortunately not aged rats. A protected basal forebrain cholinergic system, which could well be one out of several neuronal manifestations of lifelong environmental enrichment, might have contributed to the behavioral benefits of this enrichment.
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页码：1027 / 1043
页数：16
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