Synthesis, Characterization and Antimicrobial Activity of Two Novel Sulfonamide Schiff Base Compounds

Reactions of 2-hydroxy-3-methoxybenzaldehyde with p-toluenesulfonyl hydrazide and 4-nitrosulfonyl hydrazide under classical heating led to the corresponding sulfonamide Schiff bases 1 and 2. Both synthesized compounds were characterized by their spectroscopic data and elemental analysis. The antimicrobial activity of 1 and 2 against Gram-positive bacteria Staphylococcus epidermidis and Staphylococcus saprophyticus and Gram-negative bacteria Proteus mirabilis has been investigated by disc diffusion and minimum inhibitory concentration (MIC) methods. The disc diffusion method was also used to study antifungal activity of compounds against Aspergillus fumigates, Aspergillus clavatus, and Aspergillus flavus. Vancomycin and sulfamethoxazole/trimethoprim were used as standard drugs for bacteria and miconazole was used as antifungal standard.