Acyclic analogs of pyrimidine nucleosides. Synthesis of 1-(2-hydroxyethoxymethyl)- and 1-(4-hydroxybutyl)-5-amino derivatives of uracil

被引：0
|
作者：
Novikov M.S. [1 ]
Ozerov A.A. [1 ]
机构：
[1] Scientific-Research Institute of Pharmacology, Volgograd Medical Academy
来源：
Chemistry of Heterocyclic Compounds | 1998年 / 34卷 / 7期
关键词：
Organic Chemistry; Pyrimidine; Nucleoside; Uracil; Antiviral Agent;
D O I：
10.1007/BF02251694
中图分类号：
学科分类号：
摘要：
With the objective of discovering new antiviral agents based on acyclic analogs of pyrimidine nucleosides, we have synthesized 1-(2-hydroxyethoxymethyl)- and 1-(4-hydroxybutyl) derivatives of uracil having various aromatic and heterocyclic amino-containing substituents in the 5 position of the pyrimidine ring. ©1999 Kluwer Academic/Plenum Publishers.
引用
收藏
页码：841 / 847
页数：6
相关论文
共 50 条
  • [1] Acyclic analogs of pyrimidine nucleosides. Synthesis of 1-(2-hydroxyethoxymethyl)- and 1-(4-hydroxybutyl)-5-amino derivatives of uracil
    Scientific-Research Institute of Pharmacology, Volgograd Medical Academy, Volgograd 400066, Russia
    Chemistry of Heterocyclic Compounds, 1998, 34 (07): : 841 - 847
  • [2] Acyclic analogs of pyrimidine nucleosides. Synthesis of uracil 1-(2-hydroxyethoxy)methyl- and 1-(4-hydroxybutyl)-5-amino derivatives
    Novikov, MS
    Ozerov, AA
    KHIMIYA GETEROTSIKLICHESKIKH SOEDINENII, 1998, (07): : 971 - 978
  • [3] PYRIMIDINE ACYCLIC NUCLEOSIDES - 1-(2-HYDROXYETHOXYMETHYL)PYRIMIDINES AS CANDIDATE ANTIVIRALS
    KELLEY, JL
    KELSEY, JE
    HALL, WR
    KROCHMAL, MP
    SCHAEFFER, HJ
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1981, 181 (MAR): : 33 - MEDI
  • [4] ANTI-HERPES SIMPLEX VIRUS AND CYTOSTATIC ACTIVITY OF SOME NEW 5-SUBSTITUTED 1-(4-HYDROXYBUTYL)-URACIL AND 1-(2-HYDROXYETHOXYMETHYL)-URACIL NUCLEOSIDE ANALOGS
    REEFSCHLAGER, J
    HERRMANN, G
    JENNRICH, H
    FROST, N
    ACTA VIROLOGICA, 1985, 29 (03) : 185 - 193
  • [5] Synthesis of polyfluoroalkyl-containing 1-(4-acetoxybutyl)- and 1-(4-hydroxybutyl)pyrazoles and their tuberculostatic activity
    Ivanova, A. E.
    Khudina, O. G.
    Burgart, Ya. V.
    Saloutin, V. I.
    Kravchenko, M. A.
    RUSSIAN CHEMICAL BULLETIN, 2011, 60 (11) : 2396 - 2400
  • [6] Synthesis of polyfluoroalkyl-containing 1-(4-acetoxybutyl)- and 1-(4-hydroxybutyl)pyrazoles and their tuberculostatic activity
    A. E. Ivanova
    O. G. Khudina
    Ya. V. Burgart
    V. I. Saloutin
    M. A. Kravchenko
    Russian Chemical Bulletin, 2011, 60 : 2396 - 2400
  • [7] NON-GLYCOSIDIC ANALOGS OF NUCLEOSIDES .3. 1-(2'-METHYLENETETRAHYDROFURYL) URACIL 1-(2'-METHYLENETETRAHYDROFURYL)THYMINE AND 1-(2'-METHYLENETETRAHYDROFURYL) CYTOSINE . 1-(2'-R-METHYLENETETRAHYDROFURYL) URACIL
    DEFAYE, J
    NAUMBERG, M
    REYNERS, T
    JOURNAL OF HETEROCYCLIC CHEMISTRY, 1969, 6 (02) : 229 - &
  • [8] Synthesis of some 4-substituted 1-(4-hydroxybutyl)pyrazolo-[3,4-d]pyrimidine analogues of 9-(4-hydroxybutyl)guanine (HBG)
    Taha, ML
    Lazrek, HB
    BULLETIN DES SOCIETES CHIMIQUES BELGES, 1995, 104 (11): : 647 - 652
  • [9] ANALOGS OF PYRIMIDINE NUCLEOSIDES .11. SYNTHESIS OF 1-(TETRAHYDROFURYL-2) DERIVATIVES OF PYRIMIDINE-BASES USING 2-ACETOXYTETRAHYDROFURAN
    ZHUK, RA
    BERZINYA, AE
    SHERIN, LA
    KAULINYA, LT
    HILLER, SA
    KHIMIYA GETEROTSIKLICHESKIKH SOEDINENII, 1977, (09): : 1258 - 1259
  • [10] SIMPLIFIED ANALOGS OF ACYCLONUCLEOSIDES - SYNTHESIS OF 6-[N-ALKYL-N-(4-HYDROXYBUTYL)AMINO]PYRIMIDINE DERIVATIVES
    BOTTA, M
    SALADINO, R
    ANZINI, M
    CORELLI, F
    NUCLEOSIDES & NUCLEOTIDES, 1994, 13 (08): : 1769 - 1777
12345