Aging-related characteristics of growth hormone receptor/binding protein gene-disrupted mice

被引：0
|
作者：
Karen T. Coschigano
机构：
[1] Ohio University,Department of Biomedical Sciences, College of Osteopathic Medicine
来源：
AGE | 2006年 / 28卷
关键词：
aging; gene disruption; growth hormone receptor/binding protein; longevity; mice;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Since generation of the growth hormone receptor/binding protein (GHR/BP) gene-disrupted mouse nearly 10 years ago, use of this mouse model has become widespread in the elucidation of the physiological roles of GH and insulin-like growth factor-1 (IGF-1). In particular, it serves as a useful model to study mechanisms of aging. This review highlights the evidence demonstrating that the loss of GH signaling leads to lifespan extension in mice, and presents the multiple characteristics of this mouse line that suggest the life extension is due to alteration of the aging process.
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页码：191 / 200
页数：9
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