Effect of Nipradilol on Silent Myocardial Ischemia and Heart Rate Variability in Chronic Stable Angina

被引：0
作者：
Bonpei Takase
Hiroyuki Hikita
Kimio Satomura
Takemi Mastui
Fumitaka Ohsuzu
Akira Kurita
机构：
[1] National Defense Medical College,Internal Medicine
[2] National Defense Medical College,1
来源：
Cardiovascular Drugs and Therapy | 2002年 / 16卷
关键词：
nipradilol; silent myocardial ischemia; heart rate variability;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Purpose: Silent myocardial ischemic episodes as well as decreased heart rate variability (HRV) indices are associated with an unfavorable outcome in patients with coronary artery disease. Nipradilol, which is a non-selective beta-adrenergic and nitrate-like vasodilator anti-anginal agent developed in Japan, may ameliorate silent myocardial ischemia, while it also improves exercise tolerance and HRV indices in patients with chronic stable angina.
引用
收藏
页码：43 / 51
页数：8
相关论文
共 64 条
[1]  
Kishida H(1987)Evaluation of a new antianginal agent, nipradilol, in effort angina using Holter monitoring Jpn Heart J 29 309-317
[2]  
Saito T(1992)Effect of nipradilol on cardiovascular hemodynamics during exercise in angina pectoris with old myocardial infarction Arzneimittel-Forschung Drug Research 42 1195-1199
[3]  
Nejima J(1996)Effect of Nipradilol on silent myocardial ischemia, plasma beta-endorphin and bradykinin in chronic stable angina Clin Cardiol 19 477-482
[4]  
Saito T(1996)Influence of metoprolol on heart rate variability in survivors of remote myocardial infarction Am J Cardiol 77 557-560
[5]  
Sekiya Y(1994)Effect of Bepridil on silent myocardial ischemia and eicosanoid metabolism in chronic stable angina pectoris after healing of myocardial infarction Am J Cardiol 73 1063-1068
[6]  
Yamazaki K(1992)Clinical evaluation and safety of long-term treatment of nipradilol (Hyperdil) on essential hypertension (in Japanese) Therapeutic Research 13 1605-1614
[7]  
Udaka Y(1990)Comparison between antianginal effects of various beta-adrenoceptor antagonists for angina pectoris (in Japanese) Cardioangiology 28 130-136
[8]  
Inagaki Y.(1992)Lifethreatening ventricular arrhythmia in patients with silent myocardial ischemia due to coronary-artery spasm N Engl J Med 326 1451-1455
[9]  
Takase B(1991)Cardiac events in patients with silent myocardial ischemia. Jpn Heart J 33 1013-1021
[10]  
Kurita A(1990)Silent ischemia during daily life is an independent predictor of mortality in stable angina Circ 81 748-756
1234567