Persistent symptoms and lab abnormalities in patients who recovered from COVID-19

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作者
Julian Varghese
Sarah Sandmann
Kevin Ochs
Inga-Marie Schrempf
Christopher Frömmel
Martin Dugas
Hartmut H. Schmidt
Richard Vollenberg
Phil-Robin Tepasse
机构
[1] University of Münster,Institute of Medical Informatics
[2] University Hospital Münster,Department of Medicine B, Gastroenterology and Hepatology
[3] University Hospital Heidelberg,Institute of Medical Informatics
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Scientific Reports | / 11卷
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With increasing numbers of patients recovering from COVID-19, there is increasing evidence for persistent symptoms and the need for follow-up studies. This retrospective study included patients without comorbidities, who recovered from COVID-19 and attended an outpatient clinic at a university hospital for follow-up care and potential convalescent plasma donation. Network analysis was applied to visualize symptom combinations and persistent symptoms. Comprehensive lab-testing was ascertained at each follow-up to analyze differences regarding patients with vs without persistent symptoms. 116 patients were included, age range was 18–69 years (median: 41) with follow-ups ranging from 22 to 102 days. The three most frequent persistent symptoms were Fatigue (54%), Dyspnea (29%) and Anosmia (25%). Lymphopenia was present in 13 of 112 (12%) cases. Five of 35 cases (14%) had Lymphopenia in the later follow-up range of 80–102 days. Serum IgA concentration was the only lab parameter with significant difference between patients with vs without persistent symptoms with reduced serum IgA concentrations in the patient cohort of persistent symptoms (p = 0.0219). Moreover, subgroup analyses showed that patients with lymphopenia experienced more frequently persistent symptoms. In conclusion, lymphopenia persisted in a noticeable percentage of recovered patients. Patients with persistent symptoms had significantly lower serum IgA levels. Furthermore, our data provides evidence that lymphopenia is associated with persistence of COVID-19 symptoms.
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