Characterisation of insulin-resistant phenotype of cultured rat primary adipose cells

被引:0
作者
C. C. Xiang
Y. J. Wu
L. Ma
L. Ding
I. Lisinski
M. J. Brownstein
S. W. Cushman
X. Chen
机构
[1] J. Craig Venter Institute,Laboratory of Functional Genomics
[2] Mount Sinai School of Medicine,Division of Endocrinology, Diabetes and Bone Disease, Department of Medicine
[3] University of Minnesota,Department of Food Science and Nutrition–Room 139
[4] Diabetes Branch,Experimental Diabetes, Metabolism, and Nutrition Section
[5] NIDDK/NIH,undefined
来源
Diabetologia | 2007年 / 50卷
关键词
Adipocyte; Adipokine; Dysregulation; Endocrine; Gene expression; Insulin resistance; Metabolism; Microarray; Mitochondria; Obesity;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
页码:1070 / 1079
页数:9
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  • [1] Heilbronn L(2004)Failure of fat cell proliferation, mitochondrial function and fat oxidation results in ectopic fat storage, insulin resistance and type II diabetes mellitus Int J Obes Relat Metab Disord 28 S12-S21
  • [2] Smith SR(2000)Obesity and insulin resistance J Clin Invest 106 473-481
  • [3] Ravussin E(2001)Central role of the adipocyte in the metabolic syndrome J Investig Med 49 119-126
  • [4] Kahn BB(2000)Molecular mechanisms of insulin resistance and the role of the adipocyte Int J Obes Relat Metab Disord 24 S23-S27
  • [5] Flier JS(1997)Elevated levels of SREBP-2 and cholesterol synthesis in livers of mice homozygous for a targeted disruption of the SREBP-1 gene J Clin Invest 100 2115-2124
  • [6] Bergman RN(1993)Regulation of the GLUT4/muscle-fat glucose transporter mRNA in adipose tissue of insulin-deficient diabetic rats J Biol Chem 268 640-644
  • [7] Van Citters GW(2003)Standard isolation of primary adipose cells from mouse epididymal fat pads induces inflammatory mediators and down-regulates adipocyte genes J Biol Chem 278 47585-47593
  • [8] Mittelman SD(1984)The fate of labelled glucose molecules in the rat adipocyte. Dependence on glucose concentration Biochim Biophys Acta 804 68-76
  • [9] Hotamisligil GS(1997)Protein-tyrosine phosphatases PTP1B and syp are modulators of insulin-stimulated translocation of GLUT4 in transfected rat adipose cells J Biol Chem 272 8026-8031
  • [10] Shimano H(2004)Selective gene expression in magnocellular neurons in rat supraoptic nucleus J Neurosci 24 7174-7185