The clinical efficacy of artemether/lumefantrine (Coartem®)

被引：0
作者：
Michael Makanga
Srivicha Krudsood
机构：
[1] Francie van Zijl Drive,European & Developing Countries Clinical Trials Partnership (EDCTP)
[2] Parow,WHO CC for Clinical Management of Malaria
[3] Faculty of Tropical Medicine,undefined
[4] Mahidol University,undefined
来源：
Malaria Journal | / 8卷
关键词：
Malaria; Falciparum Malaria; Artesunate; Parasite Clearance; Artemether;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Current World Health Organization (WHO) guidelines for the treatment of uncomplicated falciparum malaria recommend the use of artemisinin-based combination therapy (ACT). Artemether/lumefantrine is an ACT prequalified by the WHO for efficacy, safety and quality, approved by Swissmedic in December 2008 and recently approved by the USA FDA. Coartem® is a fixed-dose combination of artemether and lumefantrine. Its two components have different modes of action that provide synergistic anti-malarial activity. It is indicated for the treatment of infants, children and adults with acute, uncomplicated infection due to Plasmodium falciparum or mixed infections including P. falciparum. A formulation with improved palatability has been developed especially for children (Coartem® Dispersible), which rapidly disperses in a small amount of water for ease of administration.
引用
收藏
相关论文
共 416 条
[1]  
White NJ(1999)Clinical pharmacokinetics and pharmacodynamics of artemether/lumefantrine Clin Pharmacokinet 37 105-125
[2]  
van Vugt M(2009)The global portfolio of new antimalarial medicines under development Clin Pharmacol & Therapeutics 85 584-595
[3]  
Ezzet F(1999)Efficacy of six doses of artemether/lumefantrine (benflumetol) in multidrug-resistant Am J Trop Med Hyg 60 936-942
[4]  
Olliaro P(2000) malaria Trans R Soc Trop Med Hyg 94 545-548
[5]  
Wells TNC(2001)Artemether/lumefantrine for the treatment of multi-drug resistant falciparum malaria Am J Trop Med Hyg 64 247-256
[6]  
van Vugt M(2005)A clinical and pharmacokinetic trial of six doses of artemether/lumefantrine for multidrug-resistant Trans R Soc Trop Med Hyg 99 459-467
[7]  
Wilairatana P(2008) malaria in Thailand Lancet 372 1819-1827
[8]  
Gemperli B(2008)Efficacy and safety of artemether/lumefantrine (Coartem Am J Trop Med Hyg 78 241-247
[9]  
Gathmann I(2006)) tablets (six-dose regimen) in African infants and children with acute, uncomplicated falciparum malaria PLoS Clin Trials 1 e7-2219
[10]  
Phaipun L(2007)Efficacy and safety of artemether/lumefantrine dispersible tablets compared with crushed commercial tablets in African infants and children with uncomplicated malaria: a randomised, single-blind, multicentre trial JAMA 297 2210-1087
12345678910