Synthesis and transformations of new 3-oxo(thioxo)-1-phenyl-2,3,5,6,7,8-hexahydroisoquinoline-4-carboxylic acid derivatives

被引：0

作者：

I. V. Dyachenko

M. V. Vovk

机构：

[1] Taras Shevchenko Lugansk National University,Institute of Organic Chemistry

[2] National Academy of Sciences of Ukraine,undefined

来源：

Russian Journal of General Chemistry | 2012年 / 82卷

关键词：

General Chemistry; Isoquinoline; BuOH; Sodium Ethoxide; Allyl Bromide;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

By condensation of 2-benzoyl-1-(morpholin-4-yl)-1-cyanohexene with cyanoacetanilides and monothiomalonodiamide the corresponding 2-substituted 3-oxo-1-phenyl-2,3,5,6,7,8-hexahydroisoquinoline-4-carbonitriles and 3-thioxo-1-phenyl-2,3,5,6,7,8-hexahydroisoquinoline-4-carboxamide were obtained. The latter was used in the synthesis of 3-alkylthio-1-phenyl-5,6,7,8-hexahydroisoquinoline-4-carboxamides and 3,3-dimethyl-1-oxo-6-phenyl-1,2,7,8,9,10-hexahydro-3H-[1,3]thiazino[6,5-c]isoquinoline.

引用

页码：697 / 702

页数：5

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