Epigenetic mechanisms and genome stability

被引：0
作者：
Emily L. Putiri
Keith D. Robertson
机构：
[1] Medical College of Georgia,Department of Biochemistry and Molecular Biology, Cancer Research Center, CN
来源：
Clinical Epigenetics | 2011年 / 2卷
关键词：
DNA methylation; Histone modifications; Microsatellite instability (MSI); DNA repair; Centromere;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Epigenetic marks are well recognized as heritable chemical modifications of DNA and chromatin that induce chromatin structural changes thereby affecting gene activity. A lesser-known phenomenon is the pervasive effects these marks have on genomic integrity. Remarkably, epigenetic marks and the enzymes that establish them are involved in multiple aspects of maintaining genetic content. These aspects include preserving nucleotide sequences such as repetitive elements, preventing DNA damage, functioning in DNA repair mechanisms and chromatin restoration, and defining chromosomal organization through effects on structural elements such as the centromere. This review discusses these functional aspects of epigenetic marks and their effects on human health and disease.
引用
收藏
页码：299 / 314
页数：15
相关论文
共 1005 条
  • [1] Ahuja N(1997)Association between CpG island methylation and microsatellite instability in colorectal cancer Cancer Res 57 3370-3374
  • [2] Mohan AL(2008)Epigenetic regulation of centromeric chromatin: old dogs, new tricks? Nat Rev Genet 9 923-937
  • [3] Li Q(2002)Neocentromeres: role in human disease, evolution, and centromere study Am J Hum Genet 71 695-714
  • [4] Stolker JM(2002)CENP-A, -B, and -C chromatin complex that contains the I-type alpha-satellite array constitutes the prekinetochore in HeLa cells Mol Cell Biol 22 2229-2241
  • [5] Herman JG(2006)Chromatin signatures of pluripotent cell lines Nat Cell Biol 8 532-538
  • [6] Hamilton SR(2003)Germline mutations at microsatellite loci in homozygous and heterozygous mutants for mismatch repair and PCNA genes in DNA Repair (Amst) 2 827-833
  • [7] Baylin SB(2001)Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain Nature 410 120-124
  • [8] Issa JP(1999)MED1, a novel human methyl-CpG-binding endonuclease, interacts with DNA mismatch repair protein MLH1 Proc Natl Acad Sci USA 96 3969-3974
  • [9] Allshire RC(2002)Methylation of histone H3 Lys 4 in coding regions of active genes Proc Natl Acad Sci USA 99 8695-8700
  • [10] Karpen GH(2006)A bivalent chromatin structure marks key developmental genes in embryonic stem cells Cell 125 315-326
12345678910