A novel SNP of the Hesx1 gene in bovine and its associations with average daily gain

被引：25

作者：

Lai, Xinsheng ^{[1
]}

Lan, Xianyong ^{[1
]}

Chen, Hong ^{[1
,2
]}

Wang, Xinlei ^{[1
]}

Wang, Keyi ^{[1
]}

Wang, Mou ^{[1
]}

Yu, Hui ^{[1
]}

Zhao, Miao ^{[1
]}

机构：

[1] NW A&F Univ, Coll Anim Sci & Technol, Shaanxi Key Lab Mol Biol Agr, Yangling 712100, Shaanxi, Peoples R China

[2] Xuzhou Normal Univ, Inst Cellular & Mol Biol, Xuzhou 221116, Jiangsu, Peoples R China

来源：

MOLECULAR BIOLOGY REPORTS | 2009年 / 36卷 / 07期

基金：

中国国家自然科学基金;

关键词：

Cattle; Hesx1; gene; SNP; Average daily gain; SEPTO-OPTIC DYSPLASIA; PITUITARY; EXPRESSION; MUTATIONS; HYPOPITUITARISM; HYPOPLASIA; TRAITS; MOUSE;

D O I：

10.1007/s11033-008-9368-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

As an essential repressor, the homeobox gene Hesx1/HESX1 is required within the anterior neural plate for normal forebrain development. Mutations within the Hesx1 gene have been associated with GH deficiency or combined pituitary hormone deficiency. We detected the polymorphism of Hesx1 gene by PCR-SSCP and DNA sequencing methods in 702 individuals from four Chinese cattle breeds. A novel single nucleotide polymorphism (SNP) (IVS1 + 382T > C) was detected. The frequencies of genotype TC in four breeds were 0.000-0.222. Polymorphism of the Hesx1 gene was shown to be associated with growth in the Nanyang breed. Individuals with genotype TC was significantly lower average daily gain than TT at 18 months (P < 0.05).

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收藏

页码：1677 / 1681

页数：5

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