Inhibition of 6-phosphofructo-2-kinase (PFKFB3) induces autophagy as a survival mechanism

被引:0
|
作者
Alden C Klarer
Julie O’Neal
Yoannis Imbert-Fernandez
Amy Clem
Steve R Ellis
Jennifer Clark
Brian Clem
Jason Chesney
Sucheta Telang
机构
[1] University of Louisville,Division of Medical Oncology and Hematology, Department of Medicine, James Graham Brown Cancer Center
关键词
Autophagy; Chemotherapy; Chloroquine; Glycolysis; Reactive oxygen species;
D O I
10.1186/2049-3002-2-2
中图分类号
学科分类号
摘要
引用
收藏
相关论文
共 50 条
  • [1] Inhibition of 6-phosphofructo-2-kinase (PFKFB3) induces autophagy as a survival mechanism
    Klarer, Alden C.
    O'Neal, Julie
    Imbert-Fernandez, Yoannis
    Clem, Amy
    Ellis, Steve R.
    Clark, Jennifer
    Clem, Brian
    Chesney, Jason
    Telang, Sucheta
    CANCER & METABOLISM, 2014, 2
  • [2] Suppression of 6-Phosphofructo-2-Kinase (PFKFB3) for the treatment of breast cancer
    Imbert-Fernandez, Yoannis
    Clem, Amy
    Clem, Brian
    Tapolsky, Gilles
    Telang, Sucheta
    Chesney, Jason
    CANCER RESEARCH, 2016, 76
  • [3] Inhibition of 6-Phosphofructo-2-kinase (PFKFB3) induces cell death and synergistically enhances chemosensitivity in endometrial cancer
    Xiao, Yinan
    Jin, Ling
    Bhattacharya, Sayantani Sarkar
    Staub, Julie
    Deng, Chaolin
    Fang, Xiaoling
    Shridhar, Viji
    CANCER RESEARCH, 2020, 80 (16)
  • [4] Targeting 6-phosphofructo-2-kinase (PFKFB3) as an immunotherapeutic strategy.
    Chesney, Jason Alan
    Telang, Sucheta
    Yaddanapudi, Kavitha
    Grewal, Jaspreet Singh
    JOURNAL OF CLINICAL ONCOLOGY, 2016, 34 (15)
  • [5] Targeting 6-Phosphofructo-2-Kinase ( PFKFB3) as a Therapeutic Strategy against Cancer
    Clem, Brian F.
    O'Neal, Julie
    Tapolsky, Gilles
    Clem, Amy L.
    Imbert-Fernandez, Yoannis
    Kerr, Daniel A., II
    Klarer, Alden C.
    Redman, Rebecca
    Miller, Donald M.
    Trent, John O.
    Telang, Sucheta
    Chesney, Jason
    MOLECULAR CANCER THERAPEUTICS, 2013, 12 (08) : 1461 - 1470
  • [6] 6-Phosphofructo-2-Kinase (PFKFB3): At the crossroads of resistance to targeted cancer therapies
    Telang, Sucheta
    O'Neal, Julie
    Imbert-Fernandez, Yoannis
    Clem, Brian
    Lypova, Nadiia
    Tapolsky, Gilles H.
    Trent, John
    Chesney, Jason
    CANCER RESEARCH, 2015, 75
  • [7] Nuclear compartmentalization of a key regulator of glycolysis, 6-phosphofructo-2-kinase (PFKFB3)
    Yalcin, A
    Simmons, A
    Clem, A
    Telang, S
    Wattenberg, B
    Gray, R
    Chesney, J
    FASEB JOURNAL, 2006, 20 (05): : A1295 - A1296
  • [8] Estradiol Stimulates Glucose Metabolism via 6-Phosphofructo-2-kinase ( PFKFB3)
    Imbert-Fernandez, Yoannis
    Clem, Brian F.
    O'Neal, Julie
    Kerr, Daniel A.
    Spaulding, Robert
    Lanceta, Lilibeth
    Clem, Amy L.
    Telang, Sucheta
    Chesney, Jason
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2014, 289 (13) : 9440 - 9448
  • [9] Inhibition of 6-phosphofructo-2-kinase (PFKFB3) suppresses glucose metabolism and the growth of HER2+ breast cancer
    O'Neal, Julie
    Clem, Amy
    Reynolds, Lindsey
    Dougherty, Susan
    Imbert-Fernandez, Yoannis
    Telang, Sucheta
    Chesney, Jason
    Clem, Brian F.
    BREAST CANCER RESEARCH AND TREATMENT, 2016, 160 (01) : 29 - 40
  • [10] Simultaneous inhibition of the estrogen receptor and 6-phosphofructo-2-kinase (PFKFB3) for the treatment of ER+ breast cancer
    Yoannis Imbert-Fernandez
    Sucheta Telang
    Jason Chesney
    Cancer & Metabolism, 2 (Suppl 1)