Polygalasaponin F induces long-term potentiation in adult rat hippocampus via NMDA receptor activation

被引:0
作者
Feng Sun
Jian-dong Sun
Ning Han
Chuang-jun Li
Yu-he Yuan
Dong-ming Zhang
Nai-hong Chen
机构
[1] State Key Laboratory of Bioactive Substances and Functions of Natural Medicines,
[2] Institute of Materia Medica,undefined
[3] Chinese Academy of Medical Sciences and Peking Union Medical College,undefined
来源
Acta Pharmacologica Sinica | 2012年 / 33卷
关键词
polygalasaponin F; hippocampus; long-term potentiation; NMDA receptor (NMDAR); Ca; /calmodulin-dependent kinase II (CaMKII); extracellular signal-regulated kinase (ERK); cAMP response element binding protein (CREB);
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
页码:431 / 437
页数:6
相关论文
共 146 条
[1]  
Chung IW(2002)Behavioural pharmacology of polygalasaponins indicates potential antipsychotic efficacy Pharmacol Biochem Behav 71 191-5
[2]  
Moore NA(1998)Antitussive and expectorant effects of four saponins isolated from Chin Pharm J 3 491-20
[3]  
Oh WK(1995) wild Chem Pharm Bull 43 115-9
[4]  
O'Neill MF(2009)Studies on the constituents of Acta Pharmacol Sin 30 1211-41
[5]  
Ahn JS(2008) Houtt I. Structures of polygalasaponins I–X Neuropsychopharmacology 33 18-46
[6]  
Park JB(2006)Polygalasaponin XXXII from Polygala tenuifolia root improves hippocampal-dependent learning and memory Eur J Neurosci 23 2829-18
[7]  
Peng W(2006)Synaptic plasticity: multiple forms, functions, and mechanisms Biol Psychol 73 3-76
[8]  
Xu S(2007)Elements of a neurobiological theory of hippocampal function: the role of synaptic plasticity, synaptic tagging and schemas Prog Brain Res 163 567-92
[9]  
Zhang D(1995)Mnemonic functions of the hippocampus: a comparison between animals and humans Exp Neurol 131 83-41
[10]  
Miyase T(1995)A behavioral analysis of dentate gyrus function J Biol Chem 270 20036-35