Cross-neutralization of Omicron BA.1 against BA.2 and BA.3 SARS-CoV-2

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作者：
Jing Zou
Chaitanya Kurhade
Hongjie Xia
Mingru Liu
Xuping Xie
Ping Ren
Pei-Yong Shi
机构：
[1] University of Texas Medical Branch,Department of Biochemistry and Molecular Biology
[2] University of Texas Medical Branch,Department of Pathology
[3] University of Texas Medical Branch,Sealy Institute for Drug Discovery
[4] University of Texas Medical Branch,Institute for Human Infection and Immunity
[5] University of Texas Medical Branch,Institute for Translational Sciences
[6] University of Texas Medical Branch,Sealy Institute for Vaccine Sciences
来源：
Nature Communications | / 13卷
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摘要：
The Omicron SARS-CoV-2 has several distinct sublineages, among which sublineage BA.1 is responsible for the initial Omicron surge and is now being replaced by BA.2 worldwide, whereas BA.3 is currently at a low frequency. The ongoing BA.1-to-BA.2 replacement underscores the importance to understand the cross-neutralization among the three Omicron sublineages. Here we test the neutralization of BA.1-infected human sera against BA.2, BA.3, and USA/WA1-2020 (a strain isolated in late January 2020). The BA.1-infected sera neutralize BA.1, BA.2, BA.3, and USA/WA1-2020 SARS-CoV-2s with geometric mean titers (GMTs) of 445, 107, 102, and 16, respectively. Thus, the neutralizing GMTs against heterologous BA.2, BA.3, and USA/WA1-2020 are 4.2-, 4.4-, and 28.4-fold lower than the GMT against homologous BA.1, respectively. These findings have implications in COVID-19 vaccine strategy.
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