miR-31 promotes proliferation of colon cancer cells by targeting E2F2

被引：0
|
作者：
Tong Li
Wenjing Luo
Kunmei Liu
Xiaobo Lv
Tao Xi
机构：
[1] China Pharmaceutical University,School of Life Science and Technology
[2] China Pharmaceutical University,Jiangsu Key Laboratory of Carcinogenesis and Intervention
[3] Ningxia Medical University,Ningxia Key Laboratory of Cerebrocranial Diseases
来源：
Biotechnology Letters | 2015年 / 37卷
关键词：
Anti-cancer drug design; Colon cancer cells; E2F2; MicroRNA-31; Proliferation; Survivin; Tumor suppression;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
MicroRNA-31 (miR-31) plays important roles in colon cancer development. However, the underlying mechanism is still not clear. We have explored the functions of miR-31 on proliferation of colon cancer cells as well as the underlying mechanism. E2F2 was identified as a direct target of miR-31. miR-31 regulated the proliferation of colon cancer cells by targeting E2F2. Moreover, in the present study, E2F2 acted as a tumor suppressor in colon cancer by repressing the expression of survivin and regulating the expression of CCNA2, C-MYC, MCM4 and CDK2. A possible mechanism for the function of miR-31 on colon cancer proliferation is presented and indicates that miR-31 might become a target for anti-cancer drug design.
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页码：523 / 532
页数：9
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